Polydopamine (PDA) has been gradually applied in wound healing of various types in the last three years. Due to its rich phenol groups and unique structure, it can be combined with a variety of ...materials to form wound dressings that can be used for chronic infection, tissue repair in vivo and serious wound healing. PDA complex has excellent mechanical properties and self-healing properties, and it is a stable material that can be used for a long period of time. Unlike other dressings, PDA complexes can achieve both photothermal therapy and electro activity. In this paper, wound healing is divided into four stages: antibacterial, anti-inflammatory, cell adhesion and proliferation, and re-epithelialization. Photothermal therapy can improve the bacteriostatic rate and remove reactive oxygen species to inhibit inflammation. Electrical signals can stimulate cell proliferation and directional migration. With low reactive oxygen species (ROS) levels, inflammatory factors are down-regulated and growth factors are up-regulated, forming regular collagen fibers and accelerating wound healing. Finally, five potential development directions are proposed, including increasing drug loading capacity, optimization of drug delivery platforms, improvement of photothermal conversion efficiency, intelligent electroactive materials and combined 3D printing.
Abstract The ability to realize high-fidelity quantum communication is one of the many facets required to build generic quantum computing devices. In addition to quantum processing, sensing, and ...storage, transferring the resulting quantum states demands a careful design that finds no parallel in classical communication. Existing experimental demonstrations of quantum information transfer in solid-state quantum systems are largely confined to small chains with few qubits, often relying upon non-generic schemes. Here, by using a superconducting quantum circuit featuring thirty-six tunable qubits, accompanied by general optimization procedures deeply rooted in overcoming quantum chaotic behavior, we demonstrate a scalable protocol for transferring few-particle quantum states in a two-dimensional quantum network. These include single-qubit excitation, two-qubit entangled states, and two excitations for which many-body effects are present. Our approach, combined with the quantum circuit’s versatility, paves the way to short-distance quantum communication for connecting distributed quantum processors or registers, even if hampered by inherent imperfections in actual quantum devices.
Air carriers shall not readily relinquish their held flight slots. In cases where the historical flight slot pool cannot be easily altered, a pressing need arises for an allocation method that can ...efficiently utilize the incremental resources of these time slots. This paper presents an integer planning model to address the efficient allocation of incremental airport time slot resources. The model considers the capacity of key resource nodes and flight waveforms as constraints to maximize the total incremental slots. Moreover, it considers the adaptation of strategic and tactical optimization. After conducting a case study using Beijing Capital International Airport for verification, the proposed model effectively reduces potential operational delays by 66.27% while adding 366 to 397-time slots. Notably, the model demonstrates remarkable delay reduction capabilities and can serve as a valuable decision-support tool for the incremental allocation of time slots.
Drowning is a leading cause of accidental death in children under 14 years of age in Guangdong, China. We developed a statistical model to classify the risk of drowning among children based on the ...risk factors.
A multiple-stage cluster random sampling was employed to select the students in Grades 3 to 9 in two townships in Qingyuan, Guangdong. Questionnaire was a self-reported measure consisting of general information, knowledge, attitudes and activities. A univariate logistic regression model was used to preliminarily select the independent variables at a P value of 0.1 for multivariable model. Three-quarters of the participants were randomly selected as a training sample to establish the model, and the remaining were treated as a testing sample to validate the model.
A total of 8390 children were included in this study, about 12.18% (1013) experienced drowning during the past one year. In the univariate logistic regression model, introvert personality, unclear distributions of water areas on the way to school, and bad relationships with their classmates and families were positively associated with drowning. However, females, older age and lower swimming skills were negatively associated with drowning. After employing the prediction model with these factors to estimate drowning risk of the students in the testing samples, the results of Hosmer-Lemeshow tests showed non-significant differences between the predictive results and actual risk (χ2 = 5.97, P = 0.65).
Male, younger children, higher swimming skills, bad relationship with their classmates and families, introvert personality and unclear distributions of water areas on the way to school were important risk factors of non-fatal drowning among children. The prediction model based on these variables has an acceptable predictive ability.
ObjectivesPrevious studies have used latent profile analysis (LPA) to examine rural left-behind children’s anxiety. Further study is needed to identify the heterogeneous characteristics of rural ...left-behind children’s anxiety and explore the related factors.SettingA cross-sectional survey using a school-based sample was conducted in January 2018 in Qingxin district, Qingyuan city, Guangdong province.Participants1026 left-behind children (effective response rate of the questionnaire: 95.39%).Main outcome measuresProfile latent classes (LC) and anxiety disorder.ResultsThe LPA identified three anxiety LC: ‘low anxiety’ (56.6%), ‘medium anxiety’ (34.8%) and ‘severe anxiety’ (8.6%). The multinomial logistic regression model was used to predict the relationship between personal, family, school factors and anxiety. We found that the variables directly related to lower anxiety classes included age (12–14 years), harmonious or fair relationship with classmates, no neglect, harmonious parental relationship and the duration of mother migration <6 months.ConclusionsThese findings suggested the need for careful consideration of differences in anxieties among rural left-behind children. Identifying latent subgroups may provide an empirical basis for teachers and public health practitioners to implement anxiety intervention efforts.
Current methods of preserving fruit and vegetables are costly with accompanying health risks from preserver residue. ClO2 gas preservatives can regulate the respiration and transpiration of fruit and ...vegetables, kill bacteria and fungi on their surface, and prolong their postharvest shelf life. Low concentration ClO2 gas preservative will not cause safety problems and is a novel gas preservative. In this study, ethylcellulose (EC) was used as a shell material to encapsulate aqueous NaClO2 to obtain EC-NaClO2 microcapsules with core-shell structures. The microcapsules were inlaid in polyvinyl alcohol (PVA) film, and citric acid in the PVA film enters the microcapsules with water vapor, reacts with NaClO2 and releases ClO2 gas. Film-forming properties of the PVA/EC-NaClO2 film-forming fluids were evaluated considering their viscosity and viscoelastic properties. The mechanical and gas barrier properties of the films were most suitable for the preparation of litchi storage bags when the microcapsule content was 6.0 wt%. Furthermore, the highest ClO2 concentration in the storage bags was 263.22 ± 12.34 mg m−3, which could kill etiological bacteria (E. coli and L. monocytogenes) and inhibit the growth of B. cinerea. The storage bags can extend the post-harvest shelf life of litchis and maintain their sensorial properties, such as color, moisture, hardness, weight, anthocyanins and pH. Therefore, our analysis indicates that the proposed PVA/EC-NaClO2 active package films exhibit significant potential for applications in the field of fruit and vegetable postharvest storage.
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•EC-NaClO2 microcapsules loaded in PVA film can slow release ClO2 preserving gas.•Effect of ClO2 gas concentration on bacteria and fungi.•Effect of PVA/EC-NaClO2 storage bags on the organoleptic properties of litchi.•The moisture changes of litchi during storage were analyzed by LF NMR and MRI.•PVA/EC-NaClO2 active packaging membranes extend litchi postharvest shelf life.
Blueberries are highly perishable after harvest, so a simple preservation method is needed to extend the shelf life of blueberries. In this study, sodium chlorite-loaded sepiolite was added to ...polylactide solution with tartaric acid to create a ClO2 gas slow-release fresh-keeping card. The fresh-keeping card absorbs moisture in the air, which causes tartaric acid to enter the sepiolite and react with sodium chlorite to release ClO2 gas slowly. The study investigated the impact of fresh-keeping cards on the quality attributes of blueberries, including appearance, decay rate, ethylene release rate, respiration rate, hardness, ascorbic acid content, and anthocyanin concentration. Low-field nuclear magnetic technology was used to analyze the water state and distribution of blueberries during storage. The results showed that the ClO2 gas released by the fresh-keeping card can destroy ethylene in the air and kill microorganisms in blueberries, thereby delaying fruit decay.
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•A simple ClO2 gas slow-release fresh-keeping card based on PLA was developed.•The fresh-keeping card can adjust the atmosphere in the blueberry storage bottle.•Preservation experiment of blueberries was successfully performed.•LF-NMR was used to detect water morphology and water content in blueberries.
Foodborne illness and spoilage losses caused by microbial contamination or colonization are still major postharvest issues of horticultural produce. Simple treatments (such as washing and precooling) ...can only reduce microorganisms on the surface of produce and slow their growth. Chlorine dioxide (ClO2) that has been widely used in postharvest handling of fresh produce is a superior antimicrobial and preservative due to its broad-spectrum, efficient, green, and safe. However, the specific antimicrobial mechanisms and impacts on fresh produce need to be further elucidated. This paper reviews action mechanism of ClO2 based on its selective oxidation capacity, action sites, and intracellular interactions, particularly the antimicrobial effect and mechanism on different bacteria and fungi. Its antimicrobial effect is closely related to its action form (gaseous and aqueous), microbial species, treatment concentration and time. ClO2 first contacts the cell membrane wall, and then subsequently enters the cell to affect the internal components of the cell. Different biomolecules have different sensitivities to ClO2, both in vitro and in cells. We present some of the additional advantages that ClO2 shows in its postharvest application. For instance, ClO2 is able to stimulate plant innate immunity, preserve the quality characteristics of the commodity, remove hazardous factors, and as a potential controlled release agent in antimicrobial packaging. Overall, this study could provide useful information and new insights into the rational application of ClO2 for microbial safety.
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•Antimicrobial mechanism of chlorine dioxide (ClO2) is determined by oxidation ability and action site.•ClO2 stimulates plant innate immunity.•ClO2 maintains horticultural produce quality in postharvest management applications.•ClO2 is a potential controlled release agent in antimicrobial packaging.
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