The recognition of DNA Binding Proteins (DBPs) plays a crucial role in understanding biological functions such as replication, transcription, and repair. Although current sequence-based methods have ...shown some effectiveness, they often fail to fully utilize the potential of deep learning in capturing complex patterns. This study introduces a novel model, LGC-DBP, which integrates Long Short-Term Memory (LSTM), Gated Inception Convolution, and Improved Channel Attention mechanisms to enhance the prediction of DBPs. Initially, the model transforms protein sequences into Position Specific Scoring Matrices (PSSM), then processed through our deep learning framework. Within this framework, Gated Inception Convolution merges the concepts of gating units with the advantages of Graph Convolutional Network (GCN) and Dilated Convolution, significantly surpassing traditional convolution methods. The Improved Channel Attention mechanism substantially enhances the model’s responsiveness and accuracy by shifting from a single input to three inputs and integrating three sigmoid functions along with an additional layer output. These innovative combinations have significantly improved model performance, enabling LGC-DBP to recognize and interpret the complex relationships within DBP features more accurately. The evaluation results show that LGC-DBP achieves an accuracy of 88.26% and a Matthews correlation coefficient of 0.701, both surpassing existing methods. These achievements demonstrate the model’s strong capability in integrating and analyzing multi-dimensional data and mark a significant advancement over traditional methods by capturing deeper, nonlinear interactions within the data.
Shock waves are generated under high-speed impact conditions, creating extreme environments that are difficult to be simulated. Molecular dynamics (MD), as a vital tool for investigating deformation ...mechanisms of materials at the atomic scale, plays a crucial role in investigating the response of metallic materials to shock waves. Herein, we comprehensively review the state-to-the-art progress of MD study on deformation and failure mechanisms in metals under shock loading. We start the overview by summarizing different kinds of methodologies that could generate shock waves in MD simulations. Then we focus on the examination and analysis of the shock-induced plasticity and phase transition behavior in metals with different crystal structures that intrinsically experience different deformation mechanisms. We consider single crystal, bicrystal and ploycrystal metals with face-centered cubic, body-centered cubic and hexagonal closest packed structures. Furthermore, the failure mechanisms in metals under shock loading are surveyed to disclose the relationship between spallation damage and plastic deformation. Finally, a summary and future prospects of MD studies concerning deformation and failure of metals under shock loading are provided.
Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) is a group of rare and highly heterogeneous renal cell carcinoma (RCC). The translocation involving TFE3 and different fusion partners lead to ...overexpression of the chimeric protein. The purpose of this study is to explore the clinicopathological features of Xp11.2 tRCC with four common fusion subtypes.
We screened out 40 Xp11.2 tRCC patients from January 2007 to August 2021 in our institution. The diagnosis was initially confirmed by TFE3 immunohistochemistry (IHC) and fluorescence
hybridization (FISH) assay and their fusion partners were verified by RNA sequencing. Then the 40 cases were divided into two groups (DBHS family and non-DBHS family group) and a clinical comparison among the four common fusion subtypes was performed.
Among the 40 cases, 11 cases with SFPQ-TFE3 gene fusion and 7 cases with NONO-TFE3 gene fusion were classified in DBHS group, the remaining cases with ASPL-TFE3 (11 cases) or PRCC-TFE3 (11 cases) gene fusion were classified in non-DBHS group. Lymph node (LN) metastasis (P=0.027) and distant metastasis (P=0.009) were more common seen in non-DBHS family group than DBHS family group and cases in DBHS family group have better progressive-free survival (PFS) (P=0.02). In addition, ASPL-TFE3 fusion was associated with worse outcome (P=0.03) while NONO-TFE3 fusion (P=0.04) predicted a better prognosis.
Different fusion partner genes may play a functional role in various morphology, molecular and biological features of Xp11.2 tRCCs. The impact of fusion partners on clinical characteristics of Xp11.2 tRCCs deserves further exploration.
Background
Safe water, sanitation, and hygiene facilities (WASH) interventions and access to clean cooking fuels are widely recognized as important public health interventions to reduce environmental ...risk factors of undernutrition. However, limited evidence has been found associating access to WASH and clean cooking fuels with improved nutritional well-being and elucidating the mechanism behind the impact of those interventions. This paper aims to examine the relationship between WASH and clean fuel access and adolescence nutritional well-being and further to explore time spent on household chores, a socioeconomic mechanism that mediates the relationship between access to WASH and clean cooking fuels and the nutritional well-being of adolescents.
Methods
This study uses nationally representative data of the 2010 Chinese Family Panel Study, with a subsample of 3044 complete cases of adolescents aged from 10 to 16 from 2641 families in 589 communities. Multilevel logistic regressions were used to test the association between the count of WASH and clean fuel access and whether an adolescent is underweight or stunted. We further tested the mediation effects of time spent on the doing household chores.
Results
Access to a single type of facilities is not significantly associated with the probability of stunting or underweight of adolescents. However, access to more than two types of access facilities significantly reduced the odds of stunting. We also found a partial mediation effects between the count of WASH and clean fuel access and the probability of being stunted.
Conclusion
WASH and clean fuel access has significant associations with the probability of being stunted and disproportionally affects adolescent girls. Improving access to single type of facilities is not sufficient to prevent stunting. Improved water, improved sanitation, improved waste management, and access to clean fuels and electricity interplayed with each other and collectively reduced the environmental risk factors and improved the well-being of people in the community.
Based on the epidemiological characteristics of susceptibility and age selectivity for women in Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC), we inferred that estrogen was to be blamed. ...Rad54 like 2 (Rad54l2) which might be one of key effector proteins of DNA damage mediated by estrogen was downregulated in numerous cancers, however, its role in epidemiological characteristics of Xp11.2 tRCC was needed to further study. We reviewed 1005 Xp11.2 tRCC cases and collected estrogen data and then compared the onset time of Xp11.2 tRCC cases in female with estrogen changing trend. An RNA-sequencing was performed in estrogen treated HK-2 cells and subsequently bioinformatic analysis was applied based on the Cancer Genome Atlas (TCGA) and GEO database. The male-to-female ratio of Xp11.2 tRCC was 1:1.4 and the median age of onset was 29.7 years old. The onset trend of female was similar to estrogen physiological rhythm (r = 0.67, p < 0.01). In Xp11.2 tRCC and HK-2 cells after estrogen treatment, Rad54l2 was downregulated, and GSEA showed that pathways significantly enriched in DNA damage repair and cancer related clusters after estrogen treated, as well as GO and KEGG analysis. Downregulation of Rad54l2 was in numerous cancers, including renal cell carcinoma (RCC), in which Rad54l2 expression was significantly decreased in male, age over 60 years old, T2&T3&T4 stages, pathologic SII&SIII&SIV stages as well as histologic G3&G4 grades, and cox regression analysis proved that Rad54l2 expression was a risk factor for overall survival, disease-specific survival and progression-free interval in univariate analysis. There existed female predominance in Xp11.2 tRCC and Rad54l2 might play vital role in estrogen mediating female predominance in Xp11.2 tRCC.
It is generally considered that feedback control of input currents in the matrix converter (MC) is hard to be realized due to the coupling of input control and output control, which reduces the ...degree of freedom and robustness. Moreover, under unbalanced input voltages, the coupling also results in severe distortion of input currents when the commonly used feedforward compensation control method with fixed input power factor is adopted. To address these two issues, this paper proposes a feedback control strategy on the input side of MC. This strategy is based on a control method which can modify input reference currents. The input control strategy is embedded into the output control strategy and thus is the inner loop of the system control. The input-side controllers can be designed to achieve expected input control objectives and maintain the output performance at the same time. On this basis, resonant controllers are applied to regulate input currents and instantaneous active power, so as to directly eliminate the input current harmonics and meanwhile ensure the load absorbing constant active power under unbalanced input voltages. The validity and feasibility of the proposed strategy are verified by the simulation and experimental results.
Pedestrian inertial navigation technology plays an important role in indoor positioning technology. However, low-cost inertial sensors in smart devices are affected by bias and noise, resulting in ...rapidly increasing and accumulating errors when integrating double acceleration to obtain displacement. The data-driven class of pedestrian inertial navigation algorithms can reduce sensor bias and noise in IMU data by learning motion-related features through deep neural networks. Inspired by the RoNIN algorithm, this paper proposes a data-driven class algorithm, RBCN-Net. Firstly, the algorithm adds NAM and CBAM attention modules to the residual network ResNet18 to enhance the learning ability of the network for channel and spatial features. Adding the BiLSTM module can enhance the network’s ability to learn over long distances. Secondly, we construct a dataset VOIMU containing IMU data and ground truth trajectories based on visual inertial odometry (total distance of 18.53 km and total time of 5.65 h). Finally, the present algorithm is compared with CNN, LSTM, ResNet18 and ResNet50 networks in VOIMU dataset for experiments. The experimental results show that the RMSE values of RBCN-Net are reduced by 6.906, 2.726, 1.495 and 0.677, respectively, compared with the above networks, proving that the algorithm effectively improves the accuracy of pedestrian navigation.
We theoretically propose a wide-angle, polarization-independent, and broadband nearly perfect absorber, which consists of an array of concentric multisplit circular rings on top of dielectric spacer ...and a metallic mirror. The numerical simulation results show that the average absorption reaches 97.2% over the wavelength range from 585 to 800 nm whatever the polarization angle is. Meanwhile, the absorber keeps high absorption efficiency when the incidence angle is below 45°. The physical mechanism is analyzed by calculating the absorbed power spectra and electromagnetic field distribution. The broadband and the high absorption mainly result from the strong electromagnetic resonance and overlapping of resonant frequencies. Our proposed plasmonic absorbers have potential applications in spectral imaging, photodetector, solar energy, and so on.
In this paper, the predictive power control with active damping function is proposed for matrix converter (MC). In every sampling period, the values of load active power p L , load reactive power q L ..., and input reactive power q i at the period after next are predicted. The best switching state is selected based on the minimum cost function g for the next sampling time interval, where g is the sum of the absolute errors between the reference and the predicted values. Since p L , q L , and q i are equally important for MC control, their weighting factors are fixed at 1, rather than being adjusted empirically. On this basis, a novel active damping control strategy is realized by modifying the reference values of load active power and input reactive power. By applying the active damping function, the input filter resonances which are liable to be excited by predictive control are effectively suppressed. Experimental results have verified the feasibility and validity of the proposed strategy.
Pruritus is the most common symptom of dermatological disorders, and prurigo nodularis (PN) is notorious for intractable and severe itching. Conventional treatments often yield disappointing ...outcomes, significantly affecting patients' quality of life and psychological well-being. The pathogenesis of PN is associated with a self-sustained "itch-scratch" vicious cycle. Recent investigations of PN-related itch have partially revealed the intricate interactions within the cutaneous neuroimmune network; however, the underlying mechanism remains undetermined. Itch mediators play a key role in pruritus amplification in PN and understanding their action mechanism will undoubtedly lead to the development of novel targeted antipruritic agents. In this review, we describe a series of pruritogens and receptors involved in mediating itching in PN, including cytokines, neuropeptides, extracellular matrix proteins, vasculogenic substances, ion channels, and intracellular signaling pathways. Moreover, we provide a prospective outlook on potential therapies based on existing findings.
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