Graphene oxide (GO) is reduced in dimethylacetamide by solvothermal reduction to prepare reduced graphene oxide (rGO). The thermal conductivity of rGO has been extremely improved compared with GO. ...The preparation method of poly amic acid (PAA) solution with rGO is in situ polymerization, then the uniformly dispersed solution of rGO/PAA is acquired. Polyimide (PI) nanocomposite films is prepared by the imidization of rGO/PAA nanocomposites. Transmission Electron Microscope (TEM) clearly shows the bonding of graphene and PI. The temperature of 7% weight loss of nanocomposite films exhibits a considerable increase (∼27 °C) by adding rGO. The tensile strength of nanocomposite films with 2 wt% rGO increases by 413.67% and the thermal conductivity coefficient increases by 1051.6% in comparison with pure PI films. The alignment of rGO is along the horizontal direction of films with rGO which can improve thermal decomposition temperature and thermal conductivity. Due to the tight bond of PI films and rGO, pulling out rGO needs more work during the stretching process, then the tensile properties of PI films are extremely improved.
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•Candidate genomic biomarkers were revealed for PARPis from genetic interactions.•Gain-of-function mutation of EGFR induced resistance to PARP inhibitors.•Lung cancer may benefit from ...combination of PARP inhibitor and EGFR inhibitor.•Gene set of biomarkers for PARPis contributes to the prognosis of cancer patients.
Poly (ADPribose) polymerase inhibitors (PARPis) are clinically approved drugs designed according to the concept of synthetic lethality (SL) interaction. It is crucial to expand the scale of patients who can benefit from PARPis, and overcome drug resistance associated with it. Genetic interactions (GIs) include SL and synthetic viability (SV) that participate in drug response in cancer cells. Based on the hypothesis that mutated genes with SL or SV interactions with PARP1/2/3 are potential sensitive or resistant PARPis biomarkers, respectively, we developed a novel computational method to identify them. We analyzed fitness variation of cell lines to identify PARP1/2/3-related GIs according to CRISPR/Cas9 and RNA interference functional screens. Potential resistant/sensitive mutated genes were identified using pharmacogenomic datasets. We identified 41 candidate resistant and 130 candidate sensitive PARPi-response related genes, and observed that EGFR with gain-of-function mutation induced PARPi resistance, and predicted a combination therapy with PARP inhibitor (veliparib) and EGFR inhibitor (erlotinib) for lung cancer. We also revealed that a resistant gene set (TNN, PLEC, and TRIP12) in lower grade glioma and a sensitive gene set (BRCA2, TOP3A, and ASCC3) in ovarian cancer, which were associated with prognosis. Thus, cancer genome-derived GIs provide new insights for identifying PARPi biomarkers and a new avenue for precision therapeutics.
•The SCR properties of molecular sieve catalysts are discussed according to the active elements.•The preparation, structure, hydrothermal aging properties and effects of poisoning of molecular sieve ...catalysts are described in depth.•A detailed description of the NH3-SCR reaction mechanism of molecular sieve catalysts is presented.•Provides an outlook on the development of molecular sieve catalysts.
NH3-SCR technology is a highly efficient denitrification technology that is widely used in the purification of diesel exhaust and coal-fired flue gas from thermal power plants. Molecular sieve catalysts have been extensively investigated for their high activity and selectivity. In this review, the preparation, structure, active sites and some resistances of Cu-based molecular sieve catalysts, Fe-based molecular sieve catalysts and composite metal molecular sieve catalysts are systematically investigated for relevant elaboration. In addition, the NH3-SCR reaction mechanism over the catalysts is also explained. With the increasingly stringent requirements of NOx emission, we need to develop more efficient catalysts. This paper provides a summary of the hydrothermal aging stability and the inorganic element (S / P / Alkali and alkaline earth metal) poisoning mechanisms as well as the influence of the preparation process in the molecular sieve catalysts, and we hope this review contributes to the development of molecular sieve catalysts.
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A series of carbon-graphite films was prepared via gradient heating based on polyimide (PI) and polyacrylonitrile (PAN) films under N2 atmosphere. It was observed that the segment fracture and ...thermal cross-linking reaction occur first during the low temperature pyrolysis process of PI and PAN films, meanwhile, the thermal cross-linking reaction changes the structure of PI and PAN. When it reaches a certain temperature, the crystal structure is further improved, and the films can be transformed into polycrystalline graphite structure. With the increase of temperature, the carbon content of films gradually increases and the thermal conductivity gets better. But these two kinds of films have different carbonization processes. The carbon graphite layer prepared by PI as precursor has a relatively smaller interplanar spacing and less flaws. The thermal conductivity of the films prepared by PI is 3.9 times of the films prepared by PAN.
Solid solutions can provide a more controllable way to realize the continuous regulation of the physicochemical properties of materials; thus, they have aroused extensive attention of researchers. ...Herein, one-dimensional (1D) Cd0.85Zn0.15S solid solution nanorods (CZS NRs) are selected as the substrate photocatalyst. Then, a uniform molybdate solid solution (Cd0.85Zn0.15MoO4, CZMO) nanoshell is successfully constructed on the surface of 1D CZS NRs for photocatalytic H2 evolution (PHE) using a convenient in situ photoinduced ion-exchange method with (NH4)6Mo7O24·4H2O as a precursor. Compared with the CZS, the coated CZMO solid solution shell is more stable and can effectively protect the sulfide photocatalyst from photocorrosion. Meanwhile, as the reaction active sites, the CZMO shell also shows excellent affinity for water, and thus significantly promotes the adsorption and reaction of H2O molecules on the photocatalyst surface. More importantly, it is found that the in situ-constructed CZMO shell can form an intimate type-II heterojunction with the CZS core to further realize the efficient spatial separation of photogenerated carriers. The as-prepared core–shell CZS@CZMO solid solution heterostructure exhibits an enhanced and stable visible-light-driven PHE performance (∼8.5 mmol g–1 h–1) within 15 h of photocatalytic water splitting. On this basis, a preliminary mechanism model has been proposed.
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