A search for the hadronic decays of the h(c) meson to the final states p (p) over bar pi(+)pi(-)pi(0), p (p) over bar eta and p (p) over bar pi(0) via the process psi(3686) -> pi(0)(h)c is ...performed using (4.48 +/- 0.03) x 10(8) psi(3686) events collected with the BESIII detector. The decay channel h(c) -> p (p) over bar eta is observed for the first time with a significance greater than 5 sigma and a branching fraction of (6.41 +/- 1.74 +/- 0.53 +/- 1.00) x 10(-4), where the uncertainties are statistical, systematic, and that from the branching fraction of psi(3686) -> pi(0)(h)c. Strong evidence for the decay h(c) p (p) over bar pi(+)pi(-)pi(0) is found with a significance of 4.9 sigma and a branching fraction of (3.84 +/- 0.83 +/- 0.69 +/- 0.58) x 10(-3). The significances include systematic uncertainties. No clear signal of the decay h(c) -> p (p) over bar pi(0) is found, and an upper limit of 6.59 x 10(-4) on its branching fraction is set at the 90% confidence level.
Using 448.1 x 10(6) psi(3686) decays collected with the BESIII detector at the BEPCII e(+)e(-) storage rings, the branching fractions and angular distributions of the decays chi(cJ) -> Xi(-)(Xi) ...over bar (+) and Xi(0)(Xi) over bar (0) ( J = 0, 1, 2) are measured based on a partial-reconstruction technique. The decays chi(c1) -> Xi(0)(Xi) over bar (0) and chi(c2) -> Xi(0)(Xi) over bar (0) are observed for the first time with statistical significances of 7 sigma and 15 sigma, respectively. The results of this analysis are in good agreement with previous measurements and have significantly improved precision.
Based on e(+)e(-) collision data collected by the BESIII detector at the BEPCII collider at center-of-mass energies from 2.000 to 3.080 GeV, a partial-wave analysis is performed for the process ...e(+)e(-)-> K+K-pi(0). The Born cross section of the process e(+)e(-)-> K+K-pi(0) and its subprocesses e(+)e(-)-> phi pi(0), K*+(892)K- and K2*+(1430)K- are measured. The results for e(+)e(-)-> K+K-pi(0) and phi pi(0) are consistent with the BaBar measurements and with improved precision. By analyzing the cross sections of the subprocesses e(+)e(-)-> K*+(892)K- and K2*+(1430)K-, a structure with mass M-R = (2190 +/- 19 +/- 37) MeV/c(2) and width Gamma(R) = (191 +/- 28 +/- 60) MeV is observed with a combined statistical significance of 7.1 sigma. The measured resonance parameters suggest it can be identified as the phi(2170), thus the results provide valuable input to understand the internal nature of this state.
Potentially fatal physiologic and metabolic derangements can occur in response to bacterial infection in animals and man. Recently it has been shown that alterations in the levels of circulating ...cytokines such as IL-6 and TNF-alpha occur shortly after bacterial challenge. To understand better the role of IL-6 in inflammation, we investigated the effects of in vivo anti-mouse IL-6 antibody treatment in a mouse model of septic shock. Rat anti-mouse IL-6 neutralizing mAb was produced from splenocytes of an animal immunized with mouse rIL-6. This mAb, MP5-20F3, was a very potent and specific antagonist of mouse IL-6 in vitro bioactivity, demonstrated using the NFS60 myelomonocytic and KD83 plasmacytoma target cell lines, and also immunoprecipitated radiolabeled IL-6. Anti-IL-6 mAb pretreatment of mice subsequently challenged with lethal doses of i.p. Escherichia coli or i.v. TNF-alpha protected mice from death caused by these treatments. Pretreatment of E. coli-challenged mice with anti-IL-6 led to an increase in serum TNF bioactivity, in comparison to isotype control antibody, implicating IL-6 as a negative modulator of TNF in vivo. Anti-TNF-alpha treatment of mice challenged i.p. with live E. coli resulted in a 70% decrease in serum IL-6 levels, determined by immunoenzymetric assay, compared to control antibody, thereby supporting a role for TNF-alpha as a positive regulator of IL-6 levels. We conclude that IL-6 is a mediator in lethal E. coli infection, and suggest that antagonists of IL-6 may be beneficial therapeutically in life-threatening bacterial infection.
We report new measurements of the branching fraction B(Dv), where lis either mu or tau (-> pi), based on 6.32 fbof electron-positron annihilation data collected by the BESIII experiment at six ...center-of-mass energy points between 4.178 and 4.226 GeV. Simultaneously floating the Ds -> mu mu components yields B(D -> tau) = (5.21 +/- 0.25 +/- 0.17) x 102, B(D -> mu mu) (5.35 +/- 0.13 +/- 0.16) x 103, and the ratio of decay widths R = Gamma(D -> tau tau)/Gamma -> mu&m)= 9.73-0.58 +/- 0.36, where the first uncertainties are statistical and the second systematic. No evidence of CP asymmetry is observed in the decay rates Ds +/- -> mu +/- v mu and D +/- -> tau +/-= (+2.9 +/- 4.8 +/- 1.0)%. Constraining our measurement to the Standard Model expectation of lepton universality (R = 9.75), we find the more precise results B(D -> tau = (5.22 +/- 0.10 +/- 0.14) x 10-2and A(+/-) = (-0.1 +/- 1.9 +/- 1.0)%. Combining our results with inputs external to our analysis, we determine the C -> (S) over bar quark mixing matrix element, D+ decay constant, and ratio of the decay constants to be vertical bar V vertical bar = 0.973 +/- 0.009 +/- 0.014, f D+ = 249.9 +/- 2.4 +/- 3.5 MeV, and f D+ / f D = 1.232 +/- 0.035, respectively.
Using 2.93 fb(-1) of e(+)e(-) collision data collected with the BESIII detector at a center-of-mass energy of 3.773 GeV, we measure the absolute branching fractions of the decays D-0 -> ...K(-)e(+)nu(e) and D+ -> (K) over bar (0)e(+)nu(e) to be (3.567 +/- 0.031(stat) +/- 0.025(syst))% and (8.68 +/- 0.14(stat) +/- 0.16(syst))%, respectively. Starting with the process e(+)e(- ) -> D (D) over bar, a new reconstruction method is employed to select events that contain candidates for both D -> (K) over bare(+)nu(e) and (D) over bar -> Ke(-)(nu) over bar (e) decays. The branching fractions reported in this work are consistent within uncertainties with previous BESIII measurements that selected events containing D -> (K) over bare(+)nu(e) and hadronic (D) over bar decays. Combining our results with the lifetimes of the D degrees and D+ mesons and the previous BESIII measurements leads to a ratio of the two decay partial widths of (Gamma) over bar (D0 -> K-e+)(nu e)/(Gamma) over bar (D+ -> (K) over bar 0e+)(nu e) = 1.039 +/- 0.021. This ratio supports isospin symmetry in the D-0 -> K(-)e(+)nu(e) and D+ -> (K) over bar (0)e(+)nu(e) decays within 1.9 sigma.
A novel two dimensional pure-Lagrangian vortex method based on instantaneous vorticity conserved boundary conditions (IVCBC) has been applied to investigate the hydrodynamic coefficients and patterns ...flow around two circular cylinders in side-by-side arrangements with pitch ratios T/D=1.1–7 at a high Reynolds number Re=6×104. The benchmark case of viscous flow around a circular cylinder was first carried out to validate the novel vortex method. Then simulations of the flow around two side by side circular cylinders were performed. A new scheme was proposed to distinguish the wide wake (WW) and narrow wake (NW) by judging the velocity direction of a specific point in the gap flow. The hydrodynamic coefficients and Strouhal numbers were thoroughly studied as a function of the pitch ratios. A total of five kinds of flow patterns were identified. During the investigation of biased flow, an intermediate frequency between frequencies of NW and WW was found and approached to that of a single cylinder. The results show good agreement with the previously published experimental and numerical data.
•A novel model of flow around two circular cylinders is established for high Reynolds numbers.•A new scheme is proposed for distinguishing wide wake and narrow wake.•The immediate frequency between frequencies of NW and WW is found.•.•Five flow patterns are identified.•Good agreements are obtained between the present results and previously published data.
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