Background: Although autografts are the standard procedure for bone grafting, the use of bone regeneration by means of dental pulp stem cell is an alternative that opens a new era in this field. ...Rigenera Protocol is a new technique able to provide the surgeon autologous pulp micro-grafts. Materials and Methods: At the Department of Oral Surgery, Don Orione Hospital, Bergamo, Italy, one patient underwent to sinus lift elevation with pulp stem micro-grafts gentle poured onto collagen sponge. A CT scan control was performed after 4 month and DICOM data were processed with medical imaging software which gives the possibility to use a virtual probe to extract the bone density. Pearson′s Chi-square test was used to investigate difference in bone density (BD) between native and newly formed bone. Results: BD in newly formed bone is about the double of native bone. Conclusion: This report demonstrated that micro-grafts derived from dental pulp poured onto collagen sponge are a useful method for bone regeneration in atrophic maxilla.
One of the objectives of the redevelopment project for Trajan׳s Market, which spanned from 2000 to 2002, was to rearrange the market׳s accessibility and the visiting paths that connect and cross the ...entire site. The purpose was to extensively expose its beauty and thus invite more tourists into the area. The project design consisted of a series of catwalks placed at different levels and was conceived with respect to three criteria: (1) the didactic significance of forms and materials; (2) the coherence between architectural forms, techniques, and materials with the identity of the place; and (3) the possibility of removing, if necessary, newly added elements without damaging the relics. The project also involved the rearrangement and reconstruction of the former “Giardino delle Milizie” (2002–2007) to allow public access to the archaeological stratification and to the ancient Roman street located at its bottom. Consequently, the vaults of the convent were suspended upon a system of steel beams, which, together with several wooden pillars, also support the glass roof of the space, offering a close view of the ancient Roman walls. The structure and architectural forms coincide, implying that each of these elements is necessary and genuine.
During human embryonic development, odontogenic tissues, deriving from the neural crest, remain undifferentiated until the adult age. This study was aimed at characterising the cells of the follicle ...enveloping the dental germ, due to its direct origin from neural crests. Sixty dental follicles were collected from patients aged 18 to 45 years. This research has clarified that dental follicles, if extracted in a very early stage, when dental roots did not start to be formed, contain a lineage of cells, characterised by a high degree of plasticity in comparison with other adult stem cell populations. In particular, we found that these cells share the following features with ES: (i) high levels of embryonic stem cell markers (CD90, TRA1-60, TRA1-81, OCT-4, CD133, and SSEA-4); (ii) mRNA transcripts for Nanog and Rex-1; (iii) broader potency, being able to differentiate in cell types of all three germ layer, including smooth and skeletal muscle, osteoblasts, neurons, glial cells, and adipocytes; (iv) high levels of telomerase activity; (v) ability to form embryoid bodies; (vi) ability, after injection in murine blastocysts, to be localised within the inner cell mass; (vii) no teratoma formation after injection; (viii) in vivo tissue formation after transplantation. Our results demonstrate that these cells represent a very easy accessible and extraordinary source of pluripotent cells and point out the fact that they own the cardinal feature of embryonic stem cells.
A exigência de uma vida harmoniosa não se concentra mais tão somente no universo antropológico. A diversidade de espécies, de ecossistemas, de nossa genética comum evidencia uma integração na qual o ...Homem tem insistido, historicamente, desprezar. Se algum desses “sujeitos” não pertencer à família humana, a sua exploração se torna necessária para a manutenção dos seres humanos, especialmente aos seus desejos. A Macrobioética se torna um vetor de limites para essas atitudes desmedidas. A Natureza e os Animais não são objetos. Por esse motivo, o objetivo geral deste estudo é determinar como a Macrobioética favorece o esclarecimento das integrações entre humanos e não humanos na rede dos sistemas vivos e ressalta a importância de atitudes éticas e jurídicas para que haja, respectivamente, o perene cuidado e exigibilidade dessas condutas quando se perceber a omissão para que haja uma vida mais equilibrada.
O parkinsonismo é um distúrbio do sistema nervoso de maior incidência masculina do que feminina, visto que, por mecanismos fisiológicos, o estrogênio possui efeitos neuroprotetores, com funções como ...aumento da dopamina, um neurotransmissor essencial para o controle das funções motoras. Além disso, previne a formação dos corpúsculos de Lewy e da agregação da α-sinucleína, responsáveis pela progressão da Doença de Parkinson. Por isso, a doença se apresenta diferentemente nas mulheres. A remoção cirúrgica de ambos os ovários em mulheres na pré-menopausa para a prevenção do câncer de ovário parece favorecer o surgimento da doença, tendo em vista a perda da produção do hormônio protetor. Assim, o objetivo do estudo é analisar a associação entre a ooforectomia bilateral precoce e o desenvolvimento de parkinsonismo e Doença de Parkinson em mulheres na pré-menopausa. Trata-se de uma revisão bibliográfica sistemática, do tipo quantitativa, que utilizou as plataformas do PubMed, SciELO e Cochrane Library como bases de dados para seleção dos artigos, todos na língua inglesa. Foram utilizadas literaturas publicadas com recorte temporal de 2017 a 2022. De acordo com as literaturas analisadas, a ooforectomia bilateral precoce em mulheres na pré-menopausa aumenta o risco do desenvolvimento de parkinsonismo. Desse modo, a diminuição dos procedimentos cirúrgicos profiláticos para câncer de ovário nas pacientes com risco médio de malignidade reduziria o risco dessa condição.
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