Splitting of the nuclei of comets into multiple components has been frequently observed but, to date, no main-belt asteroid has been observed to break up. Using the Hubble Space Telescope, we find ...that main-belt asteroid P/2013 R3 consists of 10 or more distinct components, the largest up to 200 m in radius (assumed geometric albedo of 0.05) each of which produces a coma and comet-like dust tail. A diffuse debris cloud with total mass ~2 x 10 super(8) kg further envelopes the entire system. The velocity dispersion among the components, Delta V ~ 0.2-0.5 m s super(-1), is comparable to the gravitational escape speeds of the largest members, while their extrapolated plane-of-sky motions suggest a break up between 2013 February and September. The broadband optical colors are those of a C-type asteroid. We find no spectral evidence for gaseous emission, placing model-dependent upper limits to the water production rate < or =1 kg s super(-1). Breakup may be due to a rotationally induced structural failure of the precursor body.
ABSTRACT
Background: This is the 31st Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of January 1, 2013, 57 of the nation's poison ...centers (PCs) uploaded case data automatically to NPDS. The upload interval was 8.08 7.10, 11.63 (median 25%, 75%) minutes, creating a near real-time national exposure and information database and surveillance system.
Methodology: We analyzed the case data tabulating specific indices from NPDS. The methodology was similar to that of previous years. Where changes were introduced, the differences are identified. Poison center (PC) cases with medical outcomes of death were evaluated by a team of 38 medical and clinical toxicologist reviewers using an ordinal scale of 1-6 to assess the Relative Contribution to Fatality (RCF) of the exposure to the death.
Results: In 2013, 3,060,122 closed encounters were logged by NPDS: 2,188,013 human exposures, 59,496 animal exposures, 806,347 information calls, 6,116 human-confirmed nonexposures, and 150 animal-confirmed nonexposures. Total encounters showed a 9.3% decline from 2012, while health care facility human exposure calls were essentially flat, decreasing by 0.1%.All information calls decreased 21.4% and health care facility (HCF) information calls decreased 8.5%, medication identification requests (drug ID) decreased 26.8%, and human exposures reported to US PCs decreased 3.8%. Human exposures with less serious outcomes have decreased 3.7% per year since 2008 while those with more serious outcomes (moderate, major or death) have increased by 4.7% per year since 2000.
The top five substance classes most frequently involved in all human exposures were analgesics (11.5%), cosmetics/personal care products (7.7%), household cleaning substances (7.6%), sedatives/hypnotics/antipsychotics (5.9%), and antidepressants (4.2%). Sedative/hypnotics/antipsychotics exposures as a class increased most rapidly (2,559 calls/year) over the last 13 years for cases showing more serious outcomes. The top five most common exposures in children of 5 years or less were cosmetics/personal care products (13.8%), household cleaning substances (10.4%), analgesics (9.8%), foreign bodies/toys/miscellaneous (6.9%), and topical preparations (6.1%). Drug identification requests comprised 50.7% of all information calls. NPDS documented 2,477 human exposures resulting in death with 2,113 human fatalities judged related (RCF of 1, undoubtedly responsible; 2, probably responsible; or 3, contributory).
Conclusions: These data support the continued value of PC expertise and need for specialized medical toxicology information to manage the more severe exposures, despite a decrease in calls involving less severe exposures. Unintentional and intentional exposures continue to be a significant cause of morbidity and mortality in the United States. The near real-time, always current status of NPDS represents a national public health resource to collect and monitor US exposure cases and information calls. The continuing mission of NPDS is to provide a nationwide infrastructure for public health surveillance for all types of exposures, public health event identification, resilience response and situational awareness tracking. NPDS is a model system for the nation and global public health.
This research was conducted because the process of implementing the 2013 curriculum at SD Negeri Kp. Bulak III Pamulang has not been optimal, so learning is not optimal due to the lack of several ...technological tools that support the learning process in the 2013 curriculum. The purpose of this study is to determine the implementation process, and assessment. This research is a qualitative descriptive study. The subjects of this study were grade 1 - 6 teachers at SDN Kp. Bulak III Pamulang. While the object of his research is the implementation of the 2013 curriculum learning process in these elementary schools. Data collection techniques were obtained through observation and interviews. The data analysis technique uses the steps of reduction, presentation and conclusion drawing. The results showed that the implementation of the 2013 curriculum learning process in SDN Bp. Bulak III Pamulang, Pamulang Subdistrict, South Tangerang City was as follows: (1). Planning has gone according to the rules of the learning material. (2). The learning process in class is in accordance with the lesson plan, but there are still obstacles in time management and learning media. (3). Assessment has not gone well because the implementation has used thematic, but in its assessment the teacher must conduct an assessment per subject.
O objetivo deste estudo foi identificar a aderência de empresas industriais aos critérios do programa de integridade estabelecido na Lei Anticorrupção e a implantação de controles internos. Para ...tanto, foi realizada uma pesquisa descritiva, de levantamento a partir da aplicação de questionário, atingindo uma amostra de 74 indústrias, dentre as quais, 30% possuem acima de 41 anos de atividades, enquanto 68% possuem gestão familiar e/ou mista. Os resultados evidenciaram que as empresas compreendidas na amostra possuem maior aderência em alguns critérios do programa de integridade estabelecido na lei. Entretanto, ainda há oportunidades de melhorias em seus sistemas de controle. Ao observar se as empresas possuem um código de ética, conduta e integridade, 51% possuem o referido documento; 64% indicaram que ocorre no ambiente corporativo a promoção de treinamentos sobre o tema e no que se refere à existência de um comitê de ética ou compliance e um canal de denúncias, o percentual de adesão pode ser considerado relativamente baixo, sendo 22% e 24%. Ao abordar sobre a adoção de procedimentos e controles internos para evitar a ocorrência de conflitos de interesses e fraudes, 50% das empresas possuem estes procedimentos e 15% não souberam responder. Observou-se que a Lei 12.846/2013 ainda é pouco conhecida, há uma conscientização quanto a sua importância a fim de diminuir o risco de corrupção, conflito de interesses e aumentar o grau de transparência das ações, mas ao mesmo tempo, muitas entidades ainda não possuem políticas e procedimentos implementados.
Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone which is essential in eukaryotes. It is required for the activation and stabilization of a wide variety of client proteins and ...many of them are involved in important cellular pathways. Since Hsp90 affects numerous physiological processes such as signal transduction, intracellular transport, and protein degradation, it became an interesting target for cancer therapy. Structurally, Hsp90 is a flexible dimeric protein composed of three different domains which adopt structurally distinct conformations. ATP binding triggers directionality in these conformational changes and leads to a more compact state. To achieve its function, Hsp90 works together with a large group of cofactors, termed co-chaperones. Co-chaperones form defined binary or ternary complexes with Hsp90, which facilitate the maturation of client proteins. In addition, posttranslational modifications of Hsp90, such as phosphorylation and acetylation, provide another level of regulation. They influence the conformational cycle, co-chaperone interaction, and inter-domain communications. In this review, we discuss the recent progress made in understanding the Hsp90 machinery.
These character values are 18 contained in the Thematic Book for Grade III Elementary School Students which can be studied by educators through analysis. This study aims to examine the analysis of ...material content in the Thematic Book for Grade III Elementary School Students Curriculum 2013 Revised Edition 2018 which contains character values. This research uses a qualitative approach with a type of document study. The subject in this study is the researcher himself. The objects used in this study are contained in data and data sources. This research data is in the form of 18 character values in the 2013 Curriculum. The data source is in the form of Thematic Books for Grade III Elementary School Students Curriculum 2013 Revised Edition 2018. The data is analyzed by content analysis method. The content analysis techniques used, namely unitizing sampling, recording, reducing, inferring, and narrating. The results of the analysis of character values studies in the Thematic Book for Grade III Elementary School Students Curriculum 2013 Revised Edition 2018 are religious, honest, tolerance, discipline, hard work, creative, independent, respect achievements, democratic, curiosity, national spirit, love of the country, friendly/communicative, love peace, love of reading, care for the environment, care for social, and responsible. By reviewing the contents of the Thematic Book for Class III Students Curriculum 2013 Revised Edition 2018, it is hoped that educators can find out the character values contained in the book and be able to help students form student character values in each of their learning activities.
Penelitian ini bertujuan untuk mengetahui implementasi manajemen pembelajaran Kurikulum 2013 di Sekolah Dasar, yang meliputi tahap perencanaan, pelaksanaan, dan evaluasi. Metode yang digunakan dalam ...penelitian ini adalah Kualitatif dengan desain penelitian lapangan. Penelitian ini dilaksanakan di MI Darul Khaeriyah Kecamatan Suli Kabupaten Luwu. Adapun hasil yang di dapatkan bahwa pelaksanaan pembelajaran Kurikulum 2013 masih dirasa perlu para guru diberi bekal dalam memahami dan mengimplementasikan Kurikulum 2013, terutama pada aspek penilaian proses dan hasil belajar. Tahap perencanaan, dimana guru masih menyusun berdasarkan hasil KKG Guru Kelas sehingga belum mengadopsi visi dan misi tiap sekolah. Tahap pelaksanaan, dimana guru telah melaksanakan sesuai yang tercantum dalam RPP, namun terkadang guru belum mengembangkan pembelajaran sesuai dengan metode bervariasi. Tahap evaluasi, dimana guru masih terfokus hanya pada penilaian akhir, bagi guru untuk penilaian proses masih dirasa sulit karena yang dinilai tiap individu sehingga guru masih mengalami kesulitan untuk menilai secara objektif.
The 2013 curriculum aims to improve and improve the quality of national education specifically in character education. This was done to answer the changing times dynamically. MTs At-Taufiq is an ...institution under the auspices of an independent Foundation both in terms of ideas, operations and finance not dependent on the Foundation. include: (1) All school staff do the 2013 curriculum planning formulation at the beginning of the new school year. (2) The school forms the 2013 curriculum team. (3) Prepares the curriculum through the MGMP of Islamic Cultural History Teachers outside MTs At-Taufiq Bogem Diwek Jombang. (4) The preparation of the lesson schedule is formulated in a meeting at the beginning of the new school year. While the implementation of the 2013 curriculum at MTs At-Taufiq Bogem Diwek Jombang on the subjects of Islamic cultural history can be described as follows: (1) apperception. (2) Exploration. (3) Consolidation of learning (4) Formation of Attitudes, Competencies, and Character. (5) Conducting an Assessment. Evaluation of the Development of 2013 Curriculum in Islamic Cultural History Subjects at MTs At-Taufiq Bogem Diwek Jombang is as follows: (1) Evaluation is carried out taking findings in Islamic cultural history teachers in the field (2) These findings are submitted at monthly evaluation meetings. The 2013 curriculum evaluation is based on the 2013 curriculum goals and the institution's vision and mission.
Aims. We present observations of 523676 (2013 UL10), a centaur orbiting between Jupiter and Uranus that is dynamically similar to the few tens of active centaurs that are currently known. Methods. We ...analysed visible BVR images of the centaur obtained at the Telescopio Nazionale Galileo (La Palma, Canary Islands, Spain) to investigate the weak comet-like activity and to derive information on the nucleus surface colours and size. Results. Centaur 523676 (2013 UL10) is the only centaur known so far that has both comet-like activity and red surface colours: its nucleus has a colour index B – R = 1.88 ± 0.11. The nucleus R magnitude (R = 20.93 ± 0.09) allowed us to derive an upper limit for its nucleus size of D ≤ 10 km. We estimated its dust production rate to be Qd ~ 10 kg s−1 at 6.2 au (just after its perihelion passage), resulting in a timescale for the surface blanketing process τB of approximately tens of years, which is very short with respect to typical dynamical lifetime inside the group. Future monitoring of 523676 (2013 UL10) is needed to further constrain the blanketing model for active centaurs and its timescale.
•Propose a new Ying-Yang firefly algorithm (YYFA) based on dimensionally Cauchy mutation.•Initialize the fireflies by good nodes set (GNS) strategy.•A designed randomly attraction model is used to ...help convergence.•Ying-Yang firefly self-learning strategy is employed to reduce the time complexity.•The YYFA algorithm has a competitive performance on CEC 2013 and constrained problems.
Firefly algorithm (FA) is a classical and efficient swarm intelligence optimization method and has a natural capability to address multimodal optimization. However, it suffers from premature convergence and low stability in the solution quality. In this paper, a Yin-Yang firefly algorithm (YYFA) based on dimensionally Cauchy mutation is proposed for performance improvement of FA. An initial position of fireflies is specified by the good nodes set (GNS) strategy to ensure the spatial representativeness of the firefly population. A designed random attraction model is then used in the proposed work to reduce the time complexity of the algorithm. Besides, a key self-learning procedure on the brightest firefly is undertaken to strike a balance between exploration and exploitation. The performance of the proposed algorithm is verified by a set of CEC 2013 benchmark functions used for the single objective real parameter algorithm competition. Experimental results are compared with those of other the state-of-the-art variants of FA. Nonparametric statistical tests on the results demonstrate that YYFA provides highly competitive performance in terms of the tested algorithms. In addition, the application in constrained engineering optimization problems shows the practicability of YYFA algorithm.
PDF
