The tsunami caused by the Tonga submarine volcanic eruption that occurred at 13:15 Japan Time (JST) on January 15, 2022, exposed a blind spot in Japan’s tsunami monitoring and warning system, which ...was established in 1952 for local tsunamis and expanded to distant tsunamis after the 1960 Chile tsunami. This paper summarizes how the warning system responded to the unprecedented tsunami, the actual evacuation process, and the damage it caused in Japan. Initially, the tsunami from the volcanic eruption was expected to arrive at approximately midnight with amplitudes of less than 20 cm. However, a series of short waves arrived at approximately 21:00, a few hours earlier than expected. The early arrival of these sea waves coincided with a rapid increase in atmospheric pressure; then, the short-period component was predominant, and the wave height was amplified while forming wave groups. After a 1.2 m tsunami was observed in Amami City in southern Japan at 23:55 JST, the Japan Meteorological Agency issued a tsunami warning/advisory. The tsunami continued, and all advisories were cleared at 14:00 JST on January 16. Information about this tsunami and the response to it are summarized here, including the characteristics and issues of the actual tsunami evacuation situation in each region. There were no casualties, but the issues that emerged included difficulty evacuating on a winter night and traffic congestion due to evacuation by car and under the conditions of the COVID-19 pandemic. In the coastal area, damage to fishing boats and aquaculture facilities was reported due to the flow of the tsunami. In addition, damage to aquaculture facilities, including those producing oysters, scallops, seaweed and other marine products, decreased the supply of marine products, and the economic impact is likely to increase in the future.
This book provides a systematic analysis of the Russian-Ukraine war, using the concept of resilient fighting power to assess the operational performance of both sides during the first year of the ...full-scale invasion. The Russian war in Ukraine began in 2014 and continued for eight years, before the full-scale invasion of 24 February 2022. It is not a new war, but the intensity of the warfighting revived many discussions about the conduct of inter-state warfare, which has not been seen in Europe for decades. This book does not aim to offer an exhaustive operational analysis of the war, but rather provides a preliminary systematic analysis across various domains of warfare using the concept of fighting power to assess the operational performance of both sides. First, the book discusses the conceptual component and the post-Cold War adaptations of the Soviet strategic tradition by both the Ukrainian and the Russian Armed Forces. Following that, it gives an evaluation of the various aspects of warfighting in the land, air, maritime and cyber domains. Then, the book examines the role of international allied assistance, sanctions and weapons delivery in strengthening the resilience of the Ukrainian Armed Forces. The book concludes with some comments on the role of inter-state warfare in the current strategic environment and future warfare. This book will be of much interest to students of military and strategic studies, defence studies, foreign policy, Russian studies and international relations.
This volume examines Russia’s war on Ukraine. Scholars who have lived through the Russian invasion or who have conducted ethnographic research in the region for decades provide timely analysis of a ...war that will leave a lasting mark on the twenty-first century. Using the concept of dispossession, this volume showcases some of the novel ways violence operates in the Russian-Ukrainian war and the multiple means by which civilians, within the conflict zone and beyond, have become active participants in the war effort. Anthropological perspectives on war provide on-the-ground insight, historically informed analysis, and theoretical engagement to depict the experiences of dispossession by war and the motivations that drive the responses of the dispossessed. Such perspectives humanize the victims even as they depict the very inhumanity of war. Dispossession is geared towards upper-level undergraduate and graduate students, scholars, and the general reader who seeks to have a deeper understanding of the Russian-Ukrainian war as it continues to impact geopolitics more broadly.
The Role of miRNAs in Gliomas in Response to Hypoxia Smith, Louise; Chakraborty, Sajib; Lourdusamy, Anbarasu ...
Neuro-oncology (Charlottesville, Va.),
10/2022, Letnik:
24, Številka:
Supplement_4
Journal Article
Recenzirano
Odprti dostop
Abstract
AIMS
Identifying significant miRNAs that are either under or overexpressed in hypoxia compared to normoxia in glioma cells. Further exploring the effect and role of hypoxia on miR-92a-3p and ...miR-149-5p in gliomas in apoptotic and cellular senescence pathways.
METHOD
A range of glioma cells were used for screening, including primary cell lines: GIN28 and GIN31; low-grade cell lines: LGG19 and LGG24; a paediatric cell line: SF188 and a commercially available glioblastoma cell line U87. These cells were cultured at both 1% (hypoxia) and 20% (normoxia) oxygen levels. Screening of miRNAs was achieved by quantitative polymerase chain reaction (qPCR) using miRNA specific primers. Knockdowns/in were achieved by transfecting with miR-92a-3p and miR-149-5p mimics and inhibitors. Caspase-glo assay was used to assess the effect of hypoxia on apoptosis.
RESULTS
A range of miRNAs were differentially expressed in hypoxia in a range of glioma cell lines. miRNA 92a-3p and miR-149-5p were found to be downregulated and upregulated respectively in primary gliomablastoma cells in hypoxia compared to normoxia. These particular miRNAs are also found to have multiple targets in apoptosis and cellular senescence.
CONCLUSION
The screening of 90 miRNAs among the different categories of gliomas highlighted multiple miRNAs that were significant in hypoxia compared to normoxia. Using primary cell lines have identified hypoxia-affected miRNAs in glioblastomas. This discovery will increase our knowledge and understanding of the hypoxia effect on miRNAs which may aid and direct targeted therapy to conquer hypoxia in glioblastomas.
