The article is devoted to the manifestation of one of the most popular trends in modern musical culture in the vocal duet of the style of classical crossover. The subject of the study was the famous ...Barcelona duet performed by the world pop star Freddie Mercury and the queen of the opera stage Montserrat Caballé. The paper examines the poetic content, the musical language and composition of the song, as well as the nature of the dialogical interaction of the duet participants
This study examines the process of remembering and unremembering around the physical monumentality associated with historic military control over the city of Barcelona and its surrounding region. In ...particular, it looks at the Parc de Ciutadella, Barcelona’s primary public park and green space, where a major fortification was built in the eighteenth century to pacify and control the city, following the siege of Barcelona in 1714 and the subsequent oppression of the Catalan region by the Bourbons. Deliberately destroyed in the nineteenth century, it was perceived at that time as a hated symbol of repression, a perception that has continued in the literature and through various interpretative schemes in the city’s heritage centres and museums. Memory around the site is contested and selective and has been deployed in the officially constructed narratives of separatism.
Background: The Barcelona Clinic Liver Cancer (BCLC) intermediate and advanced stages (BCLC B and C) of hepatocellular carcinoma (HCC) both include heterogeneous populations. Patients classified as ...BCLC stage B present with different tumour burdens, and the recommended treatment is transarterial chemoembolization (TACE). A similar heterogeneity of tumour burden and liver function can be found among patients classified as BCLC stage C, which includes diverse clinical features (performance status PS 1–2), macrovascular invasion (MVI) including portal vein tumour (PVT) thrombosis, and/or extra-hepatic spread. Nonetheless, the anti-tumoural treatment formally recommended by Western guidelines is systemic therapy with sorafenib. Summary: Several proposals of subclassification for both these stages have been suggested in recent years, differentiating the more appropriate treatments for each substage. In particular, for BCLC stage C patients with PVT, therapeutic indications, clinical outcomes, and response to locoregional therapy are notably different in the presence of subsegmental, segmental or main PVT. Accordingly, liver resection and transarterial therapies, such as TACE or transarterial embolization (TAE) and 90Y-radioembolization (TARE), can be performed in locally advanced HCC with intrahepatic MVI according to its extent. In fact, surgery and TACE/TAE/TARE have no contraindications in the presence of PVT limited to the subsegmental or segmental branches in Child-Pugh class A patients, whereas only TARE should be utilized when there is lobar branch involvement. The presence of PS 1 should not be sufficient to allocate patients to the advanced stage since this would preclude any potential treatment for HCC. Patients should be properly classified as BCLC C only in cases of main portal trunk PVT, and treated according to the guidelines, provided that they belong to Child-Pugh class A. Key Messages: Subclassifications of BCLC B and C stages are urgently needed and require validation in order to guide clinicians towards the most effective treatment option.
Scholars of Jewish history have paid consistent and devoted attention to the Barcelona Disputation of 1263. Records of this event preserve contemporary Jewish and Christian responses to the ...proceedings, which pitted Nahmanides, the most important exegete and teacher of the region, against a convert from Judaism to Christianity, took place in the royal court before an illustrious audience. This essay traces trends in scholarly treatments of the Barcelona Disputation from the early days of the Wissenschaft des Judentums to the present. By examining challenges of veracity posed by the documentary sources as well as foundational assumptions about what the medieval authors intended to achieve with their accounts, this article provides broad overview of the historiography that has developed around the Barcelona Disputation.
The spatial concentration of tourists poses a challenge for many cities. Understanding the projected and perceived images of the city via social networks may help to improve management of this ...phenomenon. That said, social networks tend to be studied in quite a uniform way. The present study analyses the differences that could exist between 784 images posted on the Instagram network by tourist boards (projected) and 10.590 posted by visitors (perceived). The study is based on the case of Barcelona. The use of cartographic analysis tools indicates that tourist boards tend to focus on just a few specific locations. Nevertheless, user-generated images show a wider range of locations, which multiplies by seven the area where the images of the tourist board are concentrated. That said, in both cases, the images posted tend to be located in the central areas of cities. The fact that Instagram tends to reinforce the image of central spaces and that it has only a limited capacity to promote new tourist attractions outside what are already the most consolidated areas for tourism has been underlined.
•Location of user-generated and tourist board image in Instagram has been compared.•A partial coincidence is observed in the spatial distribution of images.•The tourist board focus on what are already consolidated tourist areas for tourism.•Visiting tourists project a richer and more diverse image of the city.•Instagram tends to reinforce the image of central spaces.
The GALAD score has improved early hepatocellular carcinoma (HCC) detection rate. The role of the GALAD score in staging and predicting tumor characteristics or clinical outcome of HCC remains of ...particular interest.
To determine the diagnostic/prognostic performances of the GALAD score at various phases of initial diagnosis, tumor features, and 1-year mortality of HCC and compare the performance of the GALAD score with those of other serum biomarkers.
This prospective, diagnostic/prognostic study was conducted among patients with newly diagnosed HCC at the liver center of Vajira Hospital. Eligible patients had HCC staging allocation using the Barcelona Clinic Liver Cancer (BCLC) categorization. Demographics, HCC etiology, and HCC features were recorded. Biomarkers and the GALAD score were obtained at baseline. The performance of the GALAD score and biomarkers were prospectively assessed.
Exactly 115 individuals were diagnosed with HCC. The GALAD score increased with disease severity. Between BCLC-0/A and BCLC-B/C/D, the GALAD score predicted HCC staging with an area under the curve (AUC) of 0.868 (95%CI: 0.80-0.93). For identifying the curative HCC, the AUC of GALAD score was significantly higher than that of Alpha-fetoprotein (AFP) (0.753) and Lens culinaris agglutinin-reactive fraction of AFP-L3 (0.706), and as good as that of Protein induced by vitamin K absence-II (PIVKA-II) (0.897). For detecting aggressive features, the GALAD score gave an AUC of 0.839 (95%CI: 0.75-0.92) and significantly outperformed compared to that of AFP (0.761) and AFP-L3 (0.697), with a trend of superiority to that of PIVKA-II (0.772). The performance to predict 1-year mortality of GALAD score (AUC: 0.711, 95%CI: 0.60-0.82) was better than that of AFP (0.541) and as good as that of PIVKA-II (0.736). The optimal cutoff value of GALAD score was ≥ 6.83, with a specificity of 72.63% for exhibiting substantial reduction in the 1-year mortality.
The GALAD model can diagnose HCC at the curative stage, including the characteristic of advanced disease, more than that by AFP and AFP-L3, but not PIVKA-II. The GALAD score can be used to predict the 1-year mortality of HCC.
Aminopolycarboxylates, like ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA), are chelating agents widely used in several industrial, agricultural, and domestic ...applications. However, the fact that they are not biodegradable leads to the presence of considerable amounts in aquatic systems, with serious environmental consequences. The replacement of these compounds by biodegradable alternatives has been the object of study in the last three decades. This paper reviews the most relevant studies towards the use of environmentally friendly chelating agents in a large number of applications: oxidative bleaching, detergents and cleaning compositions, scale prevention and reduction, remediation of soils, agriculture, electroplating, waste treatment, and biocides. Nitrilotriacetic acid (NTA), ethylenediaminedisuccinic acid (EDDS), and iminodisuccinic acid (IDS) are the most commonly suggested to replace the nonbiodegradable chelating agents. Depending on the application, the requirements for metal complexation might differ. Metal chelation ability of the most promising compounds NTA, EDDS, IDS, methylglycinediacetic acid (MGDA), L-glutamic acid N,N-diacetic acid (GLDA), ethylenediamine-N,N′-diglutaric acid (EDDG), ethylenediamine-N,N′-dimalonic acid (EDDM), 3-hydroxy-2,2-iminodisuccinic acid (HIDS), 2-hydroxyethyliminodiacetic acid (HEIDA), pyridine-2,6-dicarboxylic acid (PDA) with Fe, Mn, Cu, Pb, Cd, Zn, Ca, and Mg was simulated by computer calculations. The advantages or disadvantages of each compound for the most important applications were discussed.
Centred around the life narratives of HIV-positive gay migrants in two Mediterranean cities, Barcelona (Catalonia/Spain) and Rome (Italy), this paper frames their decision to migrate towards the big ...city as an active strategy to escape the 'second closet', a concept introduced by Berg and Ross in 2014 to refer to the hiding of HIV-positivity by gay men to avoid negative social condemnation. In line with recent literature on gay migration that has emphasized its relational and situated character, the paper focuses on several factors leading to the decision to migrate: sexual desire and the imagery of the big city; the configuration of the welfare regime allowing free access to antiretroviral therapies (ARTs); access to employment in the services sector; and the absence of strong ties in the new city. Methodologically the paper draws from in-depth interviews conducted with 24 HIV-positive gay men between 2014 and 2016.
Future projections indicate a global increase in heat waves, especially in urban areas due to climate change and the heat island effect, leading to adverse human, economic, and environmental ...outcomes. Cities worldwide respond by integrating climate mitigation and adaptation measures. While long-term strategies dominate research, this paper explores the increasing interest in short-term solutions, examining the Barcelona Climate Shelter Network. Investigating climate shelter initiatives, it highlights the use of public or private spaces for respite during extreme heat. This model offers insights for other European cities facing escalating heat waves, encouraging reflections on reshaping public services amidst climate crises.
Urban green spaces (UGS) have been linked with a series of benefits for the environment, and for the physical health and well-being of urban residents. This is of great importance in the context of ...the aging of modern societies. However, UGS have different forms and characteristics that can determine their utilization. Common elements in UGS such as the type of vegetation and the type of surface are surprisingly understudied in regard to their relationship with the type of activity undertaken in UGS. This paper aims to explore the relationship between landscape diversity and the type of surface with the time spent and the physical activity intensity performed by seniors. To do so, this study uses GPS tracking data in combination with accelerometer data gathered from 63 seniors residing in Barcelona, Spain. Results showed that senior participants spent little time inside the analyzed UGS and sedentary behaviors (SBs) were more common than physical activities (PAs). The presence of pavement surfaces positively influenced the total time spent in UGS while gravel surfaces were negatively associated with time spent in active behaviors. The provision of well-defined and maintained paved areas and paths are some key infrastructures to be considered when designing UGS for overall urban residents and, especially, when aiming to potentiate the access for senior visitors.
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