AUTO3, the first chimeric antigen receptor (CAR) T‐cell therapy targeting both CD19 and CD22, shows promise in combination with pembrolizumab in patients with relapsed/refractory diffuse large B‐cell ...lymphoma, according to results from a phase I trial.
In the phase III KEYNOTE‐204 trial, pembrolizumab significantly improved progression‐free survival compared with brentuximab vedotin in patients with relapsed or refractory classic Hodgkin lymphoma ...(cHL), confirming pembrolizumab as the new standard of care in this setting.
In the phase I ALPHA trial, the first allogeneic “off‐the‐shelf” CAR T‐cell therapy regimen showed clinical benefits in patients with relapsed/refractory large B‐cell or follicular lymphoma.
In the era of chimeric antigen receptor (CAR) T‐cell therapy for relapsed/refractory diffuse large B‐cell lymphoma (DLBCL), a new analysis from the Center for International Blood & Marrow Transplant ...Research (CIBMTR) confirms an ongoing role for autologous transplant in patients with chemosensitive relapsed DLBCL.
Adding venetoclax to standard chemoimmunotherapy with R‐EPOCH showed promising antitumor activity in two lymphoma trials: a phase II trial of patients with previously untreated or relapsed/refractory ...Richter's syndrome and a phase I trial of patients with previously untreated aggressive B‐cell lymphoma.
Zanubrutinib, obinutuzumab, and venetoclax (BOVen), given on a treatment schedule driven by minimal residual disease milestones, is a promising approach to previously untreated chronic lymphocytic ...leukemia, according to new findings from an investigator‐initiated phase II study.
Within the set of stochastic, indecomposable, aperiodic (SIA) matrices, the class of Sarymsakov matrices is the largest known subset that is closed under matrix multiplication, and more critically ...whose compact subsets are all consensus sets. This paper shows that a larger subset with these two properties can be obtained by generalizing the standard definition for Sarymsakov matrices. The generalization is achieved by introducing the notion of the SIA index of a stochastic matrix, whose value is 1 for Sarymsakov matrices, and then exploring those stochastic matrices with larger SIA indices. In addition to constructing the larger set, this paper introduces another class of generalized Sarymsakov matrices, which contains matrices that are not SIA, and studies their products. Sufficient conditions are provided for an infinite product of matrices from this class, converging to a rank-one matrix. Finally, as an application of the results just described and to confirm their usefulness, a necessary and sufficient combinatorial condition, the "avoiding set condition," for deciding whether or not a compact set of stochastic matrices is a consensus set is revisited. In addition, a necessary and sufficient combinatorial condition is established for deciding whether or not a compact set of doubly stochastic matrices is a consensus set.
From September 23 to September 27, 2019, the VIII All-Russian Conference on Atmospheric Electricity was held in Nalchik. The conference was organized by the Russian Academy of Sciences, the A.F. ...Mozhaisk (All-Russian Academy of Sciences named after AF Mozhaisk) and the High Mountain Geophysical Institute of Roshydromet (VGI). This article describes the work of the conference and some of the provisions of the conference decision.
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