•An updated GNSS velocity field for Western Mediterranean.•Large-scale clockwise rotation of SW and W Iberian Peninsula w.r.t. Eurasia.•Fragmentation of the Western Mediterranean basin into crustal ...tectonic blocks.
A spatially dense GNSS-based crustal velocity field for the Iberian Peninsula and Northern Africa allows us to provide new insights into two main tectonic processes currently occurring in this area. In particular, we provide, for the first time, clear evidence for a large-scale clockwise rotation of the Iberian Peninsula with respect to stable Eurasia (Euler pole component: N42.612°, W1.833°, clockwise rotation rate of 0.07 deg/Myr). We favor the interpretation that this pattern reflects the quasi-continuous straining of the ductile lithosphere in some sectors of South and Western Iberia in response to viscous coupling of the NW Nubia and Iberian plate boundary in the Gulf of Cádiz. We furnish evidence for a fragmentation of the western Mediterranean basin into independent crustal tectonic blocks, which are delimited by inherited lithospheric shear structures. Among these blocks, an (oceanic-like western) Algerian one is currently transferring a significant fraction of the Nubia–Eurasia convergence rate into the Eastern Betics (SE Iberia) and likely causing the eastward motion of the Baleares Promontory. These processes can be mainly explained by spatially variable lithospheric plate forces imposed along the Nubia–Eurasia convergence boundary.
Heat Waves (HWs) have received outstanding scientific attention over the past decades, inherent to their devastating societal and environmental effects. Observed and projected trends in HWs ...characteristics differ between geographical areas and studies, due to varying regional warming rates but also the adoption of different methods to assign a HW. The present study investigates and compares long-term statistics and trends in HWs characteristics (occurrence, duration and timing) from 1900 to 2019, at a very sensitive to climate change area, the eastern Mediterranean, derived from 15 HW definitions. In addition to broadly used definitions based on air temperature thresholds, the study introduces new definitions based on bioclimatic indices, like the UTCI (Universal Thermal Climate Index) and PET (Physiologically Equivalent Temperature). The analysis revealed coherent results, especially between definitions of the same type, but also marked deviations across different definitions, with respect to the magnitude of observed trends. Statistically significant trends (p < 0.01) in the number of HWs events and frequency of HWs days have been found in the area, irrespective of HWs definition. Changes in the timing of HWs - consistent across definitions- have been also found, resulting in the lengthening of HWs season by up to 7 days/decade since the 1960s.
•Trends in heatwaves characteristics in Athens (Greece) were studied.•Multiple heatwave definitions based on climatic and bioclimatic indices were used.•A rare −120 years old- climatic record was analysed.•Coherent findings but also marked differences were found across definitions.•Earlier start and later ending of heatwaves period were detected by all definitions.
Familial Mediterranean fever is an autoinflammatory multisystem disease, which most commonly affects patients from the Mediterranean basin. This review discusses the common polymorphisms in the MEFV ...gene as well as the role of pyrin in disease pathogenesis. Patients with familial Mediterranean fever typically develop peritonitis, pleuritis, arthritis, and fever. In addition, a number of authors have reported ophthalmic features. These case reports and series are further explored in this review. Colchicine has transformed the prognosis for patients with familial Mediterranean fever. The rationale for the use of colchicine, as well as the evidence for newer biologic agents is also covered.
Pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND) is a monogenic autoinflammatory disorder with autosomal dominant inheritance and has been associated with monoallelic ...p.Ser242Arg and p.Glu244Lys variations in the MEFV gene. This dermatosis shares clinical features and pathogenesis with familial Mediterranean fever, although it is a clinically distinct entity.
To identify the genetic basis of PAAND in a consanguineous family with 2 affected children and to prescribe an effective genotype-guided treatment.
This case series study examined 2 siblings who presented with clinical features of PAAND. We sought the genetic basis of this disease with trio whole exome sequencing (trio-WES). Genome-wide homozygosity mapping provided additional evidence for causality of a sequence variant identified by trio-WES.
Association of a biallelic MEFV variation with a new form of autosomal recessive PAAND was documented by genetic analysis. Response to treatment with colchicine and a low-dose steroid was assessed clinically and experimentally.
Two siblings, a girl (proband; age 5 years) and a boy (age 2.5 years) of Iranian-Azeri ancestry born to first-cousin consanguineous parents presented with clinical features of PAAND-recurrent episodes of maculopapular and pustular rash, gastrointestinal involvement resembling inflammatory bowel disease, and intussusception with generalized mesenteric lymphadenitis. A trio-WES test detected a previously unreported homozygous missense variation, p.Ser242Gly, in both patients' MEFV gene. Genome-wide homozygosity mapping revealed shared regions of homozygosity in the patients' DNA, including 1 on chromosome 16 harboring MEFV. Whole transcriptome sequencing by RNA-sequencing revealed that the variant MEFV transcript, among the inflammasome-associated transcripts, was most upregulated, and the cell-cell receptor interaction and innate immune system pathways were most positively enriched. Under the guidance of MEFV genotype, treatment with colchicine (1 mg/d) and low-dose prednisolone (2.5 mg every other day) was started, and the patients responded well.
This case series study demonstrated successful genotype-guided treatment with colchicine and low-dose prednisolone, a low-cost therapeutic option with minimal adverse effects, in patients with a novel form of autosomal recessive PAAND. This case report examines the genetic basis of PAAND in a consanguineous family with 2 affected children and seeks to prescribe an effective genotype-guided treatment.
Quantifying denudation rates under different climatic and tectonic settings is fundamental to understanding landscape evolution. Carbonate rocks may respond differently to climatic and tectonic ...forcings than other rock types because of their tendency to dissolve congruently. Yet, there is little information on the long-term denudation rate of carbonates and their controlling factors in different settings. Here, we present the first long-term denudation rates for carbonates in the south of the Central Anatolian Plateau. We quantified the outcrop denudation rates using in-situ cosmogenic 36Cl measured in 13 rock samples to evaluate spatial variations and potential controls on the style and rate of denudation. 36Cl-derived denudation rates range from 1.92 ± 0.31 to 45.77 ± 3.91 mm/ka. On the plateau, denudation rates are strongly correlated with precipitation and are lower than the theoretical maximum dissolution rates predicted assuming zero evaporation, implying that climate exerts the major control on carbonate denudation. These results indicate that chemical weathering is the prevalent denudation style. The denudation pattern shows spatial variability with a decreasing trend from SW to NE consistent with climate zones. High-to-moderate denudation rates occur in the continental climate, while the lowest denudation rates occur in the arid plateau interior. In the Mediterranean coastal region, measured denudation rates are higher than the predicted maximum dissolution rates, reflecting the mechanical removal of overlying rock or soil. The low denudation rates in the plateau interior indicate a slowly evolving landscape with an arid climate. The physical properties of rocks showed the weakest control on carbonate denudation.
In the Central Taurides, significant infiltration of surface runoff resulted in strong subsurface karstification at the expense of surface drainage. This process caused disequilibrium between uplift and denudation and resulted in the preservation of high-elevation topography. Therefore, in the actively uplifting plateau margin, the influence of tectonics on carbonate denudation has been interfered with the impact of precipitation and subsurface karstification.
•36Cl-derived denudation rate of carbonate rocks ranges from 1.92 to 45.77 mm/ka.•Precipitation exerts a major control on denudation of carbonate rocks.•Chemical weathering is the dominant style of denudation on the plateau.•Denudation pattern shows spatial variability with a decreasing trend from SW to NE.•The efficient drainage of runoff by karstification delayed the response to uplift.
Earthquakes are a consequence of the motions of the planet's tectonic plates, yet predicting when and where they may occur, and how to prepare remain some of the shortcomings of using scientific ...knowledge to protect human life. A devastating Mw 7.0 earthquake on October 30, 2020, offshore Samos Island, Greece was a consequence of the Aegean and Anatolian upper crust being pulled apart by north-south extensional stresses resulting from slab rollback, where the African plate is subducting northwards beneath Eurasia, while the slab is sinking by gravitational forces, causing it to retreat southwards. Since the retreating African slab is coupled with the overriding plate, it tears the upper plate apart as it retreats, breaking it into numerous small plates with frequent earthquakes along their boundaries. Historical earthquake swarms and deformation of the upper plate in the Aegean have been associated with massive volcanism and cataclysmic devastation, such as the Mw 7.7 Amorgos earthquake in July 1956 between the islands of Naxos and Santorini (Thera). Even more notable was the eruption of Santorini 3650 years ago, which contributed to the fall of the Minoan civilization. The Samos earthquake highlights the long historical lack of appreciation of links between deep tectonic processes and upper crustal deformation and geological hazards, and is a harbinger of future earthquakes and volcanic eruptions, establishing a basis for studies to institute better protection of infrastructure and upper plate cultures in the region.
This study evaluates the relation of a Mediterranean dietary pattern and its individual components with the cardiovascular risk factors profile, plasma glucose and body mass index (BMI) in people ...with type 2 diabetes. We studied 2568 participants at 57 diabetes clinics. Diet was assessed with the EPIC (European Prospective Investigation into Cancer and Nutrition) questionnaire, adherence to the Mediterranean diet was evaluated with the relative Mediterranean diet score (rMED). A high compared to a low score was associated with a better quality of diet and a greater adherence to the nutritional recommendations for diabetes. However, even in the group achieving a high score, only a small proportion of participants met the recommendations for fiber and saturated fat (respectively 17% and 30%). Nonetheless, a high score was associated with lower values of plasma lipids, blood pressure, glycated hemoglobin, and BMI. The relationship of the single food items components of the rMED score with the achievement of treatment targets for plasma lipids, blood pressure, glucose, and BMI were also explored. The study findings support the Mediterranean dietary model as a suitable model for type 2 diabetes and the concept that the beneficial health effects of the Mediterranean diet lie primarily in its synergy among various nutrients and foods rather than on any individual component.
Eight months (June 2011 to January 2012) of aerosol property data were obtained at the remote site of Alborán Island (35.95°N, 3.03°W) in the western Mediterranean basin. The aim of this work is to ...assess the aerosol properties according to air mass origin and transport over this remote station with a special focus on air mass transport from North Africa. For air masses coming from North Africa, different aerosol properties showed strong contributions from mineral dust lifted from desert areas. Nevertheless, during these desert dust intrusions, some atmospheric aerosol properties are clearly different from pure mineral dust particles. Thus, Angström exponent α(440–870) presents larger values than those reported for pure desert dust measured close to dust source regions. These results combine with α(440, 670) − α(670, 870) ≥ 0.1 and low single scattering albedo (ω(λ)) values, especially at the largest wavelengths. Most of the desert dust intrusions over Alborán can be described as a mixture of dust and anthropogenic particles. The analyses support that our results apply to North Africa desert dust air masses transported from different source areas. Therefore, our results indicate a significant contribution of fine absorbing particles during desert dust intrusions over Alborán arriving from different source regions. The aerosol optical depth data retrieved from Sun photometer measurements have been used to check Moderate Resolution Imaging Spectroradiometer retrievals, and they show reasonable agreement, especially for North African air masses.
Key Points
Optical properties in the almucantar and principal plane configurationsAnthropogenic particles were transported together desert dust from North AfricaLow values of single scattering albedo during desert dust events
Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids, poor in natural antioxidants and fiber from fruits, vegetables, and whole grains, and poor in omega-3 fatty ...acids may cause an activation of the innate immune system, most likely by excessive production of proinflammatory cytokines associated with a reduced production of anti-inflammatory cytokines. The Mediterranean Diet (MedDiet) is a nutritional model inspired by the traditional dietary pattern of some of the countries of the Mediterranean basin. This dietary pattern is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat, processed meat products and seeds. Several epidemiological studies have evaluated the effects of a Mediterranean pattern as protective against several diseases associated with chronic low-grade inflammation such as cancer, diabetes, obesity, atherosclerosis, metabolic syndrome and cognition disorders. The adoption of this dietary pattern could counter the effects of several inflammatory markers, decreasing, for example, the secretion of circulating and cellular biomarkers involved in the atherosclerotic process. Thus, the aim of this review was to consider the current evidence about the effectiveness of the MedDiet in these chronic inflammatory diseases due to its antioxidant and anti-inflammatory properties, which may not only act on classical risk factors but also on inflammatory biomarkers such as adhesion molecules, cytokines or molecules related to the stability of atheromatic plaque.
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