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11.
  • Endothelial cell senescence... Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function
    Rossman, Matthew J; Kaplon, Rachelle E; Hill, Sierra D ... American journal of physiology. Heart and circulatory physiology, 11/2017, Letnik: 313, Številka: 5
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    Cellular senescence is emerging as a key mechanism of age-related vascular endothelial dysfunction, but evidence in healthy humans is lacking. Moreover, the influence of lifestyle factors such as ...
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12.
  • Inhibition of SHP2-mediated... Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
    Bunda, Severa; Burrell, Kelly; Heir, Pardeep ... Nature communications, 11/2015, Letnik: 6, Številka: 1
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    Ras is phosphorylated on a conserved tyrosine at position 32 within the switch I region via Src kinase. This phosphorylation inhibits the binding of effector Raf while promoting the engagement of ...
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13.
  • Systematic RNA interference... Systematic RNA interference reveals that oncogenic KRAS -driven cancers require TBK1
    Kim, So Young; Sabatini, David M; Michel, Kathrin ... Nature (London), 11/2009, Letnik: 462, Številka: 7269
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    The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led ...
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14.
  • RAS Synthetic Lethal Screen... RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?
    Downward, Julian Clinical cancer research, 04/2015, Letnik: 21, Številka: 8
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    The RAS genes are critical oncogenic drivers activated by point mutation in some 20% of human malignancies. However, no pharmacologic approaches to targeting RAS proteins directly have yet succeeded, ...
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15.
  • SMYD3 links lysine methylat... SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
    Mazur, Pawel K; Reynoird, Nicolas; Khatri, Purvesh ... Nature (London), 06/2014, Letnik: 510, Številka: 7504
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    Deregulation of lysine methylation signalling has emerged as a common aetiological factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed ...
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16.
  • Mapping the Conformation Sp... Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm
    Clausen, Rudy; Ma, Buyong; Nussinov, Ruth ... PLoS computational biology, 09/2015, Letnik: 11, Številka: 9
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    An important goal in molecular biology is to understand functional changes upon single-point mutations in proteins. Doing so through a detailed characterization of structure spaces and underlying ...
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17.
  • Mule/Huwe1/Arf-BP1 suppress... Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15
    Inoue, Satoshi; Hao, Zhenyue; Elia, Andrew J ... Genes & development, 2013-May-15, 2013-05-15, 20130515, Letnik: 27, Številka: 10
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    Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or senescence. Many gene products involved in these ...
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18.
  • Selective killing of oncoge... Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
    Trachootham, Dunyaporn; Zhou, Yan; Zhang, Hui ... Cancer cell, 09/2006, Letnik: 10, Številka: 3
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    Reactive oxygen species (ROS) stimulate cell proliferation and induce genetic instability, and their increase in cancer cells is often viewed as an adverse event. Here, we show that such abnormal ...
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19.
  • MEK inhibition exhibits eff... MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
    Jessen, Walter J; Miller, Shyra J; Jousma, Edwin ... The Journal of clinical investigation, 01/2013, Letnik: 123, Številka: 1
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    Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve tumors result from loss of NF1 tumor ...
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20.
  • Evolution of AF6-RAS associ... Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
    Smith, Matthew J; Ottoni, Elizabeth; Ishiyama, Noboru ... Nature communications, 10/2017, Letnik: 8, Številka: 1
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    Elucidation of activation mechanisms governing protein fusions is essential for therapeutic development. MLL undergoes rearrangement with numerous partners, including a recurrent translocation fusing ...
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