This study investigates the effect of particle size on the compression characteristics of wet- (fluid-bed granulation - FBG) and dry-granulated (slugging - DGS) tableting mixtures. Particle-size ...distribution, flowability, compressibility, using the Heckel and Walker model, compactibility and elastic recovery as well as friability and disintegration were determined and compared between the two particle size fractions (180-400 μm, 400-710 μm) and initial unsieved mixtures. The results showed that the particle size of granules had no effect on the compressibility of the FBG and DGS mixtures, due to the high fragmenting nature of the formulation used in this study. On the other hand, compactibility was particle size dependent, as larger-sized fractions showed higher crushing strength, lower friability, and lower elastic recovery. This was attributed to increased fragmentation of larger particles, allowing stronger bonding between uncontaminated surface areas. As a result of better rearrangement of particles, both initial tableting mixtures showed lower compressibility and lower compactibility compared to their sieved fractions.
V študiji smo prou~evali vpliv velikosti delcev na stisljivost vlano (vrtin~noslojno granuliranje - FBG) in suho (briketiranje - DGS) granuliranih zmesi za tabletiranje. Dvema velikostnima frakcijama vsake zmesi (180-400 μm, 400-710 μm) in primerjalno nepresejanima zmesema smo dolo~ili porazdelitev velikosti delcev, preto~nost, kompresibilnost z uporabo Heckelovega in Walkerjevega modela in kompaktibilnost. Tabletam izdelanim iz posameznih zmesi smo dolocili delez elasti~ne relaksacije, krušljivost in razpadnost. Rezultati naše študije potrjujejo, da velikost granulata ne vpliva na kompresibilnost FBG in DGS zmesi za tabletiranje, kar je posledica izrazite fragmentacijske narave uporabljene formulacije zmesi. V nasprotju s tem dejstvom pa je bil potrjen signifikanten vpliv velikosti delcev na kompaktibilnost, saj so imele tablete izdelane iz ve~jih velikostnih frakcij višjo natezno trdnost, nizjo krušljivost in nizji delez elasti~ne relaksacije. To pripisujemo izrazitejši fregmentaciji ve~jih delcev in posledi~no tvorbi mo~nejših povezav med novonastalimi ~istimi površnami delcev. Obe osnovni zmesi sta zaradi boljše za~etne prerazporeditve delcev izkazovali slabšo kompresibilnost in kompaktibilnost.
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