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zadetkov: 51.946
21.
  • Health outcomes associated ... Health outcomes associated with crack-cocaine use: Systematic review and meta-analyses
    Butler, Ainslie J.; Rehm, Jürgen; Fischer, Benedikt Drug and alcohol dependence, 11/2017, Letnik: 180
    Journal Article
    Recenzirano

    •Crack-cocaine use is common but health outcomes are not systematically reviewed.•Strong associations exist for various infectious diseases, e.g., HIV, hepatitis C.•Moderate evidence associations ...
Celotno besedilo
22.
  • A Recombinant Humanized Ant... A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Its Metabolites in Rats
    Marckel, Jordan A; Wetzel, Hanna N; Amlal, Sihame ... Drug metabolism and disposition, 03/2019, Letnik: 47, Številka: 3
    Journal Article
    Recenzirano
    Odprti dostop

    A recombinant humanized anticocaine monoclonal antibody, h2E2, has shown potential in the preclinical phases for the treatment of cocaine abuse. The standard tests for cocaine usage are the detection ...
Celotno besedilo

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23.
  • Effects of the novel relati... Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats
    Valenza, Marta; Butelman, Eduardo R.; Kreek, Mary Jeanne Psychopharmacology, 08/2017, Letnik: 234, Številka: 15
    Journal Article
    Recenzirano
    Odprti dostop

    Rationale The recruitment of the stress circuitry contributes to a shift from positive to negative reinforcement mechanisms sustaining long-term cocaine addiction. The kappa opioid receptor (KOPr) ...
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24.
  • Cocaine Use in Adolescents and Young Adults
    Ryan, Sheryl A The Pediatric clinics of North America, 12/2019, Letnik: 66, Številka: 6
    Journal Article
    Recenzirano

    Cocaine use by adolescents and young adults continues to be a significant public health issue and the cause of medical and psychological morbidity and mortality. Although use rates are lower than ...
Preverite dostopnost
25.
  • Biomarkers for the Developm... Biomarkers for the Development of New Medications for Cocaine Dependence
    BOUGH, Kristopher J; AMUR, Shashi; SHARMA, Jyoti ... Neuropsychopharmacology (New York, N.Y.), 01/2014, Letnik: 39, Številka: 1
    Journal Article
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    There has been significant progress in personalized drug development. In large part, this has taken place in the oncology field and been due to the ability of researchers/clinicians to discover and ...
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26.
  • Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder
    Howell, Leonard L; Cunningham, Kathryn A Pharmacological reviews, 2015, Letnik: 67, Številka: 1
    Journal Article
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    Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use disorder with significant morbidity. Major advances have been made in delineating neurobiological mechanisms of ...
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27.
  • Kappa-opioid receptors, dyn... Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study
    Martinez, Diana; Slifstein, Mark; Matuskey, David ... Neuropsychopharmacology (New York, N.Y.), 09/2019, Letnik: 44, Številka: 10
    Journal Article
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    Animal studies indicate that the kappa-opioid receptor/dynorphin system plays an important role in cocaine binges and stress-induced relapse. Our goal was to investigate changes in kappa-opioid ...
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28.
  • Cannabis and cocaine decrea... Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes
    Ramaekers, J. G.; van Wel, J. H.; Spronk, D. ... Brain imaging and behavior, 12/2016, Letnik: 10, Številka: 4
    Journal Article
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    The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline. We hypothesized that individuals with low activity DBH genotypes (rs1611115 CT/TT) are more sensitive to the influence ...
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29.
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30.
  • Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking
    Kohtz, Amy S; Zhao, Joshua; Aston-Jones, Gary The Journal of neuroscience, 04/2024, Letnik: 44, Številka: 17
    Journal Article
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    The initiation of abstinence after chronic drug self-administration is stressful. Cocaine-seeking behavior on the first day of the absence of the expected drug (Extinction Day 1, ED1) is reduced by ...
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