To evaluate the efficacy and safety of transcutaneous electrical stimulation (TES) for the prevention of dry eye after photorefractive keratectomy (PRK).
Prospective, single-center, single-blinded, ...parallel group, placebo-controlled, randomized clinical trial.
Between February 2020 and October 2020, patients at the Samsung Medical Center scheduled to undergo PRK to correct myopia were screened and enrolled.
The participants in the TES group were instructed to use the electrical stimulation device (Nu Eyne 01, Nu Eyne Co) at the periocular region after the operation, whereas those in the control group were to use the sham device. Dry eye symptoms were evaluated preoperatively and postoperatively at weeks 1, 4, and 12 using the Ocular Surface Disease Index (OSDI) questionnaire, the 5-Item Dry Eye Questionnaire (DEQ-5), and the Standard Patient Evaluation for Eye Dryness II (SPEED II) questionnaire. Dry eye signs were assessed using tear break-up time (TBUT), total corneal fluorescein staining (tCFS), and total conjunctival staining score according to the National Eye Institute/Industry scale. The pain intensity was evaluated using a visual analog scale.
Primary outcomes were OSDI and TBUT.
Twenty-four patients were enrolled and completed follow-up until the end of the study (12 patients in the TES group, 12 patients in the control group). Refractive outcomes and visual acuity were not different between the groups. No serious adverse event was reported with regard to device use. No significant difference in OSDI and SPEED II questionnaires and the DEQ-5 was observed between the groups in the 12th week after surgery. The TBUT scores 12 weeks after the surgery were 9.28 ± 6.90 seconds in the TES group and 5.98 ± 2.55 seconds in the control group with significant difference (P = 0.042). The tCFS and total conjunctival staining score were significantly lower in the TES group than in the control group at postoperative 4 weeks. Pain intensity at the first week was significantly lower in the TES group than in the control group by 65% (P = 0.011).
The application of TES is safe and effective in improving dry eye disease after PRK.
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Electrostimulation is a way of treatment various nerve and muscle injuries as well as acute and chronic pain conditions. The electrotherapy which is increasingly used in physiotherapy, muscle is ...exposed to an electrical pulse in order to activate excitable tissue using external electrodes with the aim of building muscle strength, enhancement healing, improvement in patient’s mobility or reducing painTextile based electrodes are significantly noticed in the aspects of being flexible and re-usable and no needs of hydrogels, thereby avoiding skin irritation and allergic reactions and enhancing user comfort. This article presents a kind of textile based electrodes made of conductive yarns containing stainless steel/plyester blend fiber. The embroidery technique was used to prepare the textile based electrodes.Samples were examined on 10 people with pain in their bodies in a hospital without being moisturised. The purpose of this study is to asses the performance of 3 different textile based electrodes, considering the conductivity of the yarns which have been used to produce textile based electrodes, the usfulness of them for electrotherapy and comparing them with rubber electrodes commonly are used in clinics regularly.
A memristor is a resistor with memory, which is a non-linear passive two-terminal electrical element relating magnetic flux linkage and electrical charge. Here we found that memristors exist in vivo. ...The electrostimulation of the Aloe vera by bipolar sinusoidal or triangle periodic waves induce electrical responses with fingerprints of memristors. Uncouplers carbonylcyanide-3-chlorophenylhydrazone and carbonylcyanide-4-trifluoromethoxy-phenyl hydrazone decrease the amplitude of electrical responses at low and high frequencies of bipolar periodic sinusoidal or triangle electrostimulating waves. Memristive behavior of an electrical network in the Aloe vera is linked to the properties of voltage gated ion channels: the K
+
channel blocker TEACl reduces the electric response to a conventional resistor. Our results demonstrate that a voltage gated K
+
channel in the excitable tissue of plants has properties of a memristor. The discovery of memristors in plants creates a new direction in the modeling and understanding of electrical phenomena in plants.
ABSTRACT Despite of being a natural physiological process, aging is considered a degenerative process with evident effects on aging skin, such as reduced elasticity, wrinkles, reduced facial fat and ...muscle tone, sagging, changes in facial contour, and sarcopenia on the face. These changes can generate social stigma, suffering, and psychological discomfort for the patient. Thus, this study aimed to evaluate the effectiveness of Neuromuscular Electrical Stimulation (NMES), a technique used in physical therapy for muscle training, in attenuating the signs of facial aging. For this purpose, a scientific survey of publications indexed on the Medline (PubMed), CINAHL, Embase, PEDro, Lilacs, ERIC, Scopus, Web of Science, and Google Scholar databases was conducted and, based on pre-established criteria, two relevant publications for the topic were selected for discussion. The scientific literature regarding the use of NMES to attenuate the signs of aging is still very scarce. The survey showed the need to discuss the current state of knowledge. Our results suggest that, theoretically, NMES could be a promising method to attenuate the signs of aging; however, there are still no conclusive results regarding the clinical effectiveness of using NMES in the facial muscles since few studies relate NMES to facial rejuvenation. More studies are needed, with greater methodological rigor and low level of bias, using precise techniques in the evaluation and allowing to interpret with greater scientific commitment of the physiological mechanism of the muscular stimulus and its interrelation with the integumentary system, proving its effectiveness in the improvement of skin appearance.
Exogenous electrical stimulation (ES) facilitates skin wound healing and accelerates cell proliferation. Scaffolds fabricated with electrically-conductive materials combined with ES further promote ...cellular activity. Here, an electrospun membrane made of poly (lactide-co-glycolide) (PLGA) coated with chitosan (CS) via polydopamine (PDA) serving as a linker was developed and evaluated in vitro for the proliferation and migration of fibroblast cells involved in skin wound repair. PLGA/PDA/CS exhibited multiple optimal characteristics for cell proliferation and dressing materials including good mechanical properties, low cytotoxicity, a super-hydrophilic surface, and an excellent swelling ratio suitable for the absorption of wound exudates. Because of ionic charges, wet PLGA/PDA/CS had an electrical conductivity of 2.85 × 10-3 S/cm, which was comparable to the highest electrical conductivities observed with natural skin. Upon intermittent ES of 100 mV, PLGA/PDA/CS increased fibroblast proliferation 2 and 1.3 times compared to PLGA and PLGA/PDA, respectively. These results demonstrate the potential of PLGA/PDA/CS as a biodegradable polymeric surface for the ES of cells involved in skin wound healing. It also shows that polymers with low electrical conductivity in dry conditions can become suitable for the ES of humid wounds where ionic conductivity is occurring.
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•A PLGA/PDA/CS membrane was fabricated for electrostimulating cell proliferation.•PLGA was electrospun and coated with adhesive PDA to anchor CS on its surface.•In humid conditions, PLGA/PDA/CS exhibits a good electrical conductivity.•Compared to PLGA and PLGA/PDA, PLGA/PDA/CS improves fibroblast electrostimulation.•PLGA/PDA/CS also has suitable wettability and swelling ratio for wound dressing.
We describe a multi-tasking flexible system that is able to release a wide spectrum antibiotic (levofloxacin, LVX) under electrostimulation and act as a pH sensor for detecting bacterial infections. ...Combining anodic polymerization with plasma polymerization processes we engineered dual pH- and electro-responsive polymeric systems. Particularly, the manufactured devices consisted on a layer of poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PHEDOT) loaded with the LVX antibiotic and coated with a plasma polymer layer of poly(acrylic acid) (PAA). The PHEDOT acted as conductive and electro-responsive agent, while the PAA provided pH responsiveness, changing from a compact globular conformation in acid environments to an expanded open coil conformation in alkaline environments. The assembly between the PHEDOT layer and the PAA coating affected the electrochemical response of the former, becoming dependent on the pH detected by the latter. The conformational change experienced by the PAA layer as a function of the pH and the redox properties of PHEDOT were leveraged for the electrochemical detection of bacteria growth and for regulating the release of the LVX antibiotic, respectively. The effectiveness of the system as a stimulus-responsive antibiotic carrier and pH sensor was also investigated on strains of Escherichia coli and Streptococcus salivarius.
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•A multi-tasking system to detect and fight against bacterial infections is shown.•Layers of electropolymerized PHEDOT and plasma polymerized PAA are coupled.•PAA provides pH responsiveness for detecting bacteria growth.•PHEDOT allows the controlled release of antibiotic by electrostimulation.•The effectiveness of the dual system is proved on different bacteria strains.
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•Two systems with identical components have been prepared for insulin release.•Despite their chemical resemblance, they exhibit very different release profiles.•In one, the release is ...rapid by diffusion and the rest by external stimulation.•In the other, the release is slow by degradation of the carrier.•The combination of the two system might allow a complete glycemic control.
Innovative insulin delivery systems contemplate combining multi-pharmacokinetic profiles for glycemic control. Two device configurations have been designed for the controlled release of insulin using the same chemical compounds. The first insulin delivery system, which displays a rapid release response that, in addition, is enhanced on a short time scale by electrical stimulation, consists on an insulin layer sandwiched between a conducting poly(3,4-ethylenedioxythiophene) (PEDOT) film and a poly-γ-glutamic acid (γ-PGA) hydrogel. The second system is constituted by γ-PGA hydrogel loaded with insulin and PEDOT nanoparticles by in situ gelation. In this case, the insulin release, which only starts after the degradation of the hydrogel over time (i.e. on a long time scale), is slow and sustained. The combination of an on-demand and fast release profile with a sustained and slow profile, which act on different time scales, would result in a very efficient regulation of diabetes therapy in comparison to current systems, allowing to control both fast and sustained glycemic events. Considering that the two systems developed in this work are based on the same chemical components, future work will be focused on the combination of the two kinetic profiles by re-engineering a unique insulin release device using γ-PGA, PEDOT and insulin.
The entrance of some toxic and hazardous chemical agents such as antibiotics, pesticides, and herbicides into the environment can cause various problems to human health and the environment. In recent ...years, researchers have considered the use of electrostimulation in the processes of microbial metabolism and biological systems for the treatment of pollutants in the environment. Although several electrostimulation reports have been presented for pollutant removal, little attention has been paid to alternative current (AC) biostimulation. This study presents a systematic review of microbial electrostimulation using bioelectrochemical systems supplied with AC. The utilization of alternating current bioelectrochemical systems (ACBESs) has some advantages such as the provide of appropriate active biofilms in the electrodes due to the cyclical nature of the current and energy transfer in an appropriate manner on the electrode surfaces. Moreover, the ACBESs can reduce hydraulic time (HRT) under optimal conditions and reduce the cost of converting electricity using AC. In microbial electrostimulation, amplitude (AMPL), waveform, C/N, and current have a significant effect on increasing the removal efficiency of the pollutants. The obtained results of the meta-analysis illustrated that various pollutants such as phenol, antibiotics, and nitrate have been removed in an acceptable range of 96% using the ACBESs. Therefore, microbial electrostimulation using AC is a promising technology for the decomposition and removal of various pollutants. Moreover, the ACBESs could provide new opportunities for promoting various bioelectrochemical systems (BES
) for the production of hydrogen or methane.
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