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  • Efficacy and safety of guse... Efficacy and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: results of the randomized, double‐blind, phase III NAVIGATE trial
    Langley, R.G.; Tsai, T.‐F.; Flavin, S. ... British journal of dermatology (1951), January 2018, 2018-01-00, 20180101, Letnik: 178, Številka: 1
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    Summary Background Guselkumab, an anti‐interleukin‐23 monoclonal antibody, has demonstrated significant efficacy in phase III psoriasis trials. Objectives To evaluate the efficacy and safety of ...
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  • Armored CAR T cells enhance... Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment
    Yeku, Oladapo O; Purdon, Terence J; Koneru, Mythili ... Scientific reports, 09/2017, Letnik: 7, Številka: 1
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    Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the management of solid tumor malignancies. In ovarian cancer, this is in part due to an immunosuppressive cytokine and ...
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  • Role of Human Macrophage Po... Role of Human Macrophage Polarization in Inflammation during Infectious Diseases
    Atri, Chiraz; Guerfali, Fatma Z; Laouini, Dhafer International journal of molecular sciences, 06/2018, Letnik: 19, Številka: 6
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    Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as ...
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  • Peripheral and lung residen... Peripheral and lung resident memory T cell responses against SARS-CoV-2
    Grau-Expósito, Judith; Sánchez-Gaona, Nerea; Massana, Núria ... Nature communications, 05/2021, Letnik: 12, Številka: 1
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    Abstract Resident memory T cells (T RM ) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, T RM are mostly non-recirculating, which ...
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  • Successful Anti-PD-1 Cancer... Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
    Garris, Christopher S.; Arlauckas, Sean P.; Kohler, Rainer H. ... Immunity (Cambridge, Mass.), 12/2018, Letnik: 49, Številka: 6
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    Anti-PD-1 immune checkpoint blockers can induce sustained clinical responses in cancer but how they function in vivo remains incompletely understood. Here, we combined intravital real-time imaging ...
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  • Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis
    Liu, Jia Jia; Wei, Ya Bin; Strawbridge, Rebecca ... Molecular psychiatry, 02/2020, Letnik: 25, Številka: 2
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    Predicting antidepressant treatment response has been a clinical challenge for major depressive disorder (MDD). The inflammation hypothesis of depression suggests that cytokines play a key role in ...
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  • The Immunobiology of the In... The Immunobiology of the Interleukin-12 Family: Room for Discovery
    Tait Wojno, Elia D.; Hunter, Christopher A.; Stumhofer, Jason S. Immunity (Cambridge, Mass.), 04/2019, Letnik: 50, Številka: 4
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    The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize ...
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  • Low Penetrance, Broad Resis... Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor β1 Deficiency
    Fieschi, Claire; Dupuis, Stéphanie; Catherinot, Emilie ... The Journal of experimental medicine, 02/2003, Letnik: 197, Številka: 4
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    The clinical phenotype of interleukin 12 receptor β1 chain (IL-12Rβ1) deficiency and the function of human IL-12 in host defense remain largely unknown, due to the small number of patients reported. ...
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