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21.
  • The clinical importance of ... The clinical importance of a cytokine network in the acute phase of sepsis
    Matsumoto, Hisatake; Ogura, Hiroshi; Shimizu, Kentaro ... Scientific reports, 09/2018, Letnik: 8, Številka: 1
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    Sepsis remains a major cause of death. Cytokines interact closely with each other and play a crucial role in the progression of sepsis. We focussed on the associations of a cytokine network with ...
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22.
  • Systematic review and netwo... Systematic review and network meta‐analysis: first‐ and second‐line biologic therapies for moderate‐severe Crohn's disease
    Singh, S.; Fumery, M.; Sandborn, W. J. ... Alimentary pharmacology & therapeutics, August 2018, Letnik: 48, Številka: 4
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    Summary Background There are limited data to inform positioning of agents for treating moderate‐severe Crohn's disease (CD). Aim We assessed comparative efficacy and safety of first‐line ...
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23.
  • Effect of IBD medications on COVID-19 outcomes: results from an international registry
    Ungaro, Ryan C; Brenner, Erica J; Gearry, Richard B ... Gut, 04/2021, Letnik: 70, Številka: 4
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    We sought to evaluate COVID-19 clinical course in patients with IBD treated with different medication classes and combinations. Surveillance Epidemiology of Coronavirus Under Research Exclusion for ...
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24.
  • Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis
    Papp, Kim A; Blauvelt, Andrew; Bukhalo, Michael ... The New England journal of medicine, 04/2017, Letnik: 376, Številka: 16
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    Interleukin-23 is thought to be critical to the pathogenesis of psoriasis. We compared risankizumab (BI 655066), a humanized IgG1 monoclonal antibody that inhibits interleukin-23 by specifically ...
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25.
  • Reactivation of the tumor s... Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
    Lin, Yao-Xin; Wang, Yi; Ding, Jianxun ... Science translational medicine, 06/2021, Letnik: 13, Številka: 599
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    Increasing clinical evidence has demonstrated that the deletion or mutation of tumor suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in ...
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26.
  • Electrophilic properties of... Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis
    Bambouskova, Monika; Gorvel, Laurent; Lampropoulou, Vicky ... Nature (London), 04/2018, Letnik: 556, Številka: 7702
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    Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring marked by the production of substantial ...
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27.
  • Interleukin 12/interleukin ... Interleukin 12/interleukin 23 pathway: Biological basis and therapeutic effect in patients with Crohn's disease
    Aggeletopoulou, Ioanna; Assimakopoulos, Stelios F; Konstantakis, Christos ... World journal of gastroenterology : WJG, 2018-Sep-28, 2018-9-28, 20180928, Letnik: 24, Številka: 36
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    Considering that both innate and adaptive immune responses are involved in the pathogenesis of Crohn's disease (CD), novel therapeutic options have significantly been developed. Biological agents ...
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28.
  • Efficacy and safety of uste... Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study
    van Vollenhoven, Ronald F; Hahn, Bevra H; Tsokos, George C ... The Lancet (British edition), 10/2018, Letnik: 392, Številka: 10155
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    Ustekinumab is a monoclonal antibody targeting interleukin (IL)-12 and IL-23 and is approved for the treatment of plaque psoriasis, psoriatic arthritis, and Crohn's disease. IL-12 and IL-23 have been ...
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29.
  • Tumor‐Associated Macrophage... Tumor‐Associated Macrophage and Tumor‐Cell Dually Transfecting Polyplexes for Efficient Interleukin‐12 Cancer Gene Therapy
    Qiu, Nasha; Wang, Guowei; Wang, Jinqiang ... Advanced materials (Weinheim), 01/2021, Letnik: 33, Številka: 2
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    Interleukin 12 (IL12) is a potent pro‐inflammatory chemokine with multifunction, including promoting cytotoxic T‐cell‐mediated killing of cancer cells. IL12‐based cancer gene therapy can overcome ...
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30.
  • IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting
    Moschen, Alexander R; Tilg, Herbert; Raine, Tim Nature reviews. Gastroenterology & hepatology, 03/2019, Letnik: 16, Številka: 3
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    IL-12 and IL-23 are closely related cytokines with important roles in the regulation of tissue inflammation. Converging evidence from studies in mice, human observational studies and population ...
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