Purpose/significance At present, the popularity of "involution" has become a cultural phenomenon, and the social reality it reflects deserves attention. Clarify the concept and characteristics of ..."involution" and measure it from a quantitative perspective, which helps to quickly seek the formation mechanism of "involution" and the path to solve it. Method/process At first, the study explained the evolution of the concept of "involution". Secondly, the evaluation index of "involution" is constructed in relation to the competition scenario of university students. Finally, we analyzed the experimental results, and gave corresponding suggestions from the three dimensions of individual and group. Result/conclusion As the randomness in the network topology decreases, the degree of competition for the "involution" of the system increases. The cooperative strategy can improve the total output of the system, while the total system input of the competitive strategy is high, but the total output of the system is l
The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes.
Thanks to improvements in genetics, nutrition, and ...management, modern dairy cows can still produce large amounts of milk at the end of lactation, with possible negative effects on health and welfare, particularly when milking is stopped abruptly. To limit yield at dry-off, strategies involving different types of dietary restriction have been used worldwide. Thus, we aimed to investigate the effects of a reduced nutrient density at dry-off on milk production, metabolism, the pattern of rumen fermentation, and milk fatty acid profile around dry-off and in the ensuing periparturient period. During the last week before dry-off, 26 Holstein cows were enrolled in pairs according to the expected calving date and either fed ad libitum ryegrass hay (nutrient restricted, NR; 13 cows) or continued to receive lactation diet (control group, CTR; 13 cows). After dry-off, both groups received only grass hay for 7 d, and free access to water was always provided. Blood, milk, and rumen fluid samples were collected from 7 d before dry-off to 28 DIM. Milk production, DMI (during the periparturient period), and rumination times were recorded daily. At dry-off, NR cows had decreased milk yield (−62%) and milk lactose compared with CTR but had higher fat and protein contents. In the subsequent lactation, no significant differences were observed in milk yield and composition. The BCS did not differ between groups during the transition period, but it decreased in NR after dry-off. Before dry-off, NR had decreased glucose, urea, and insulin, but higher creatinine, BHB, and nonesterified fatty acids (NEFA). The day after dry-off, NEFA were lower in NR, but they were higher 7 d after calving. At dry-off, NR had higher rumen pH, lower lactate, urea, and total volatile fatty acid concentrations. Considering volatile fatty acid molar proportions, NR had increased acetate but decreased propionate and butyrate at dry-off. Rumination time dropped 6 d before dry-off in NR and after dry-off in CTR, but no differences were observed in the periparturient period. Milk fatty acid profile revealed a remarkably lower proportion of short-chain fatty acids in NR at dry-off and a higher proportion of medium- and long-chain ones. These results confirmed that decreasing nutrient density reduce milk yield before dry-off. However, metabolism around dry-off was significantly affected, as suggested by plasma, rumen fluid, and milk analyses. Further research is required to investigate the impact of the metabolic effects on the inflammatory response, liver function, and immune system, particularly concerning the mammary gland.
A non-empty set \(S\) together with the ternary operation denoted by juxtaposition is said to be ternary semigroup if it satisfies the associativity property \(ab(cde)=a(bcd)e=(abc)de\) for all ...\(a,b,c,d,e\in S\). The global set of a ternary semigroup \(S\) is the set of all non empty subsets of \(S\) and it is denoted by \(P(S)\). If \(S\) is a ternary semigroup then \(P(S)\) is also a ternary semigroup with a naturally defined ternary multiplication. A natural question arises: "Do all properties of \(S\) remain the same in \(P(S)\)?" The global determinism problem is a part of this question. A class \(K\) of ternary semigroups is said to be globally determined if for any two ternary semigroups \(S_1\) and \(S_2\) of \(K\), \(P(S_1)\cong P(S_2)\) implies that \(S_1\cong S_2\). So it is interesting to find the class of ternary semigroups which are globally determined. Here we will study the global determinism of ternary \(\ast\)-band.
Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. ...Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction in immune responses, resulting from both aged innate and adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, is mainly attributed to somatic cellular senescence-associated secretory phenotype (SASP) and age-related autoimmune predisposition. However, the inability to reduce senescent somatic cells (SSCs), because of immunosenescence, exacerbates inflammaging. Age-related adaptive immune system deviations, particularly altered T cell function, are derived from age-related thymic atrophy or involution, a hallmark of thymic aging. Recently, there have been major developments in understanding how age-related thymic involution contributes to inflammaging and immunosenescence at the cellular and molecular levels, including genetic and epigenetic regulation, as well as developments of many potential rejuvenation strategies. Herein, we discuss the research progress uncovering how age-related thymic involution contributes to immunosenescence and inflammaging, as well as their intersection. We also describe how T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer. We then briefly outline the underlying cellular and molecular mechanisms of age-related thymic involution, and finally summarize potential rejuvenation strategies to restore aged thymic function.
Let D be a division ring, n an integer greater than 1 and ILn(D) the subgroup of the general linear group GLn(D) generated by all involutions in GLn(D). The aim of this paper is to show that if s is ...a natural number such that every element in the commutator group of D⁎=D﹨{0} is a product of at most s commutators in D⁎, then each matrix in ILn(D) is the product of at most 4s+4 involutions and each matrix in the special linear group SLn(D) is a product of at most 6s+4 commutators of involutions.
The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes.
The early period of mammary gland involution is a ...critical juncture in the lactation cycle that can have significant effects on milk production and mammary gland health. Pegbovigrastim (PEG) administered 1 wk prior and on the day of parturition can enhance immune function and reduce the incidence of mastitis in the early postpartum period. Oxylipids are potent metabolites of polyunsaturated fatty acids (PUFA) and are important mediators of inflammation. The objective of this study was to evaluate effects of PEG given 1 wk before and at the day of dry-off (D0) on concentrations of oxylipids in plasma and milk from 7 d before D0 to 14 d after, as well as the effects during the first 14 d of the subsequent lactation. We hypothesized that both pro- and anti-inflammatory oxylipids would vary based on initiation of mammary gland involution and that pegbovigrastim would affect oxylipid concentrations, particularly those related to leukocytes. A complete randomized blocked design was used to enroll cows into either a PEG treatment group (n = 10) or control group (n = 10; CON). Blood samples were collected −7, −2, −1, 0, 1, 2, 4, 7, and 14 d relative to dry-off and 5, 10, and 14 d postcalving. Samples were analyzed for PUFA and oxylipids in milk and plasma by ultra-performance mass spectrometry and liquid chromatography tandem quadrupole mass spectrometry, respectively. Overall, 30 lipid mediators were measured in both milk and plasma. Repeated measures analyses revealed a significant interaction of treatment by time for milk 8-iso-keto-15-prostaglandin E2, prostaglandin F2α, plasma 8,12-iso-prostaglandin Fα-VI, 11-hydroxyeicosatetraenoic acid, and 12-hydroxyheptadecatienoic acid. The majority of milk PUFA and oxylipids differed significantly during early mammary gland involution and into the early postpartum period. This study demonstrated changes in oxylipids in milk secretions and plasma during early involution, and further investigation may illuminate multiple complex processes and reveal targets for optimization of mammary gland involution.
The debate over whether involution causes anxiety has persisted because no studies have attempted to quantify introversion and study its relationship to anxiety. This study quantified involution and ...explored its relationship with anxiety, provided evidence about whether involution was related to anxiety, and created a foundation for other scholars to carry out research on involution. Interviews and questionnaires were conducted to investigate the characteristics of 535 Chinese college students’ involution behavior and its relationship with anxiety. We found that involution was not necessarily positively related to anxiety. The specific results were as follows: (1) The involution behavior of the Chinese college students could be divided into three types: the passive involution, reward-oriented involution, and achievement-motivated involution; (2) Significant differences in the involvement of involution existed at the college level; (3) Three motivations that resulted in involution, from primary to secondary, were achievement-motivation, reward-orientation, and passive engagement; and (4) Passive involution, reward-oriented involution, and the total scores for the involution behavior of the college students were significantly and positively correlated with anxiety. Among the three types of involution behavior, the college students’ passive involution had a significant and positive predictive effect on their anxiety, while achievement-motivated involution had a significant and negative predictive effect.
The presence of an autocrine factor in milk that can trigger mammary gland involution was proposed more than 50 years ago. To provide evidences that one or more autocrine factor(s) exists, 10 ...multiparous cows in late lactation were quarter-milked for 7 d. Following this baseline period, the right front quarter of each cow was left unmilked while the other quarters were milked for 7 d. Before the last milking of that period, milk (mammary secretions) was collected aseptically from both front quarters. After that milking, 250 mL of the collected samples was infused in the cows' respective rear quarters. No quarters were milked for the following 7 d (milk stasis period), and then quarter milking was resumed in all quarters for the last 7 d of the experiment (remilking period). Quarter milk samples were collected during the baseline period, before the milk stasis period, and during the remilking period. These samples were used for measuring milk components and the concentration of involution markers (SCC, BSA and lactoferrin). Samples of mammary secretions were collected manually from the quarters during the milk stasis period for involution marker determination. RNA was extracted from samples collected from front quarters before the last milking before the milk stasis period for microRNA (miRNA) determination. As anticipated, the longer milk stasis period implemented for the right front quarter resulted in a more advanced involution than in the left front quarter, based on the concentration of involution markers in the mammary secretions, lower milk production recovery and changes in milk composition during the remilking period. All 3 involution marker concentrations in the mammary secretions increased in both rear quarters, but were greater in the right quarter secretions than in the left quarter secretions. Resuming milking reinitiated milk production in all quarters, but milk production recovery in the right rear quarters was less robust than that in the left rear quarters (54.3 ± 1.4% vs 61.6 ± 1.4%, respectively). Milk from the quarters infused with mammary secretions (right rear) had a lower lactose content, but a higher milk protein content and higher SCC than the quarters infused with milk. We detected a total of 359 miRNAs, 76 of which were differentially expressed in milk and mammary secretions. Expression of bta-miR-221 and bta-miR-223 were upregulated in mammary secretions 34- and 40-fold, respectively. The results of the present experiment support the contention that milk stasis leads to the accumulation of one or more factors that trigger involution. The results also indicate that milk stasis leads to changes in the miRNA profile of the milk, but whether such changes are a cause or a consequence of the involution process remains to be established.
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