Thoughtful use of simplifying assumptions is crucial to make systems biology models tractable while still representative of the underlying biology. A useful simplification can elucidate the core ...dynamics of a system. A poorly chosen assumption can, however, either render a model too complicated for making conclusions or it can prevent an otherwise accurate model from describing experimentally observed dynamics. Here, we perform a computational investigation of sequential multi-step pathway models that contain fewer pathway steps than the system they are designed to emulate. We demonstrate when such models will fail to reproduce data and how detrimental truncation of a pathway leads to detectable signatures in model dynamics and its optimised parameters. An alternative assumption is suggested for simplifying such pathways. Rather than assuming a truncated number of pathway steps, we propose to use the assumption that the rates of information propagation along the pathway is homogeneous and, instead, letting the length of the pathway be a free parameter. We first focus on linear pathways that are sequential and have first-order kinetics, and we show how this assumption results in a three-parameter model that consistently outperforms its truncated rival and a delay differential equation alternative in recapitulating observed dynamics. We then show how the proposed assumption allows for similarly terse and effective models of non-linear pathways. Our results provide a foundation for well-informed decision making during model simplifications.
This edited volume presents a compendium of emerging and innovative studies on the proliferation of new working spaces (NeWSps), both formal and informal (such as coworking spaces, maker spaces, fab ...labs, public libraries, and coffee shops), and their role during and following the COVID-19 pandemic in urban and regional development and planning. This book presents an original, interdisciplinary approach to NeWSps through three features: (i) situating the debate in the context of the COVID-19 pandemic, which has transformed NeWSp business models and the everyday work life of their owners and users; (ii) repositioning and rethinking the debate on NeWSps in the context of socioeconomics and planning and comparing conditions between before and during the COVID-19 pandemic; and (iii) providing new directions for urban and regional development and resilience to the COVID-19 pandemic, considering new ways of working and living. The 17 chapters are co-authored by both leading international scholars who have studied the proliferation of NeWSps in the last decade and young, talented researchers, resulting in a total of 55 co-authors from different disciplines (48 of whom are currently involved in the COST Action CA18214 ‘The Geography of New Working Spaces and Impact on the Periphery’ 2019–2023: www.new-working-spaces.eu). Selected comparative studies among several European countries (Western and Eastern Europe) and from the US and Lebanon are presented. The book contributes to the understanding of multi-disciplinary theoretical and practical implications of NeWSps for our society, economy, and urban/regional planning in conditions following the COVID-19 pandemic.
Analyzing back loading during team manual handling tasks requires the measurement of external contacts and is thus limited to standardized tasks. This paper evaluates the possibility of estimating ...L5/S1 joint moments based solely on motion data. Ten subjects constituted five two-person teams and handling tasks were analyzed with four different box configurations. Three prediction methods for estimating L5/S1 joint moments were evaluated by comparing them to a gold standard using force platforms: one used only motion data, another used motion data and the traction/compression force applied to the box and one used motion data and the ground reaction forces of one team member. The three prediction methods were based on a contact model with an optimization-based method. Using only motion data did not allow an accurate estimate due to the traction/compression force applied by each team member, which affected L5/S1 joint moments. Back loading can be estimated using motion data and the measurement of the traction/compression force with relatively small errors, comparable to the uncertainty levels reported in other studies. The traction/compression force can be obtained directly with a force measurement unit built into the object to be moved or indirectly by using force platforms on which one of the two handlers stands during the handling task. The use of the proposed prediction methods allows team manual handling tasks to be analyzed in various realistic contexts, with team members who have different anthropometric measurements and with different box characteristics.
Boolean networks with asynchronous updates are a class of logical models particularly well adapted to describe the dynamics of biological networks with uncertain measures. The state space of these ...models can be described by an asynchronous state transition graph, which represents all the possible exits from every single state, and gives a global image of all the possible trajectories of the system. In addition, the asynchronous state transition graph can be associated with an absorbing Markov chain, further providing a semi-quantitative framework where it becomes possible to compute probabilities for the different trajectories. For large networks, however, such direct analyses become computationally untractable, given the exponential dimension of the graph. Exploiting the general modularity of biological systems, we have introduced the novel concept of
, computed as an interconnection of several asynchronous transition graphs and recovering all asymptotic behaviors of a large interconnected system from the behavior of its smaller modules. From a modeling point of view, the interconnection of networks is very useful to address for instance the interplay between known biological modules and to test different hypotheses on the nature of their mutual regulatory links. This paper develops two new features of this general methodology: a quantitative dimension is added to the asymptotic graph, through the computation of relative probabilities for each final attractor and a companion
is introduced to complement the method on a theoretical point of view.
En este estudio se propone una metodología computacional para aumentar la productividad a través del análisis de las operaciones optimizando el método de trabajo. Esto se enmarca en la ingeniería de ...métodos y está basada en grafos y optimización de trayectorias. Se diseñó un caso de estudio para simular un proceso de ensamble bimanual y así probar la metodología propuesta. Todas las formas de ensamble fueron convertidas en nodos que fueron obtenidos de las combinaciones de las piezas y ponderaciones de distancia entre ellas. El problema fue solucionado con el algoritmo de Dijkstra, también llamado algoritmo de caminos mínimos. La solución óptima del método fue comparada con el tiempo de operación de diez métodos seleccionados aleatoriamente de todos los posibles. Los resultados mostraron diferencias significativas entre el método óptimo y los seleccionados, encontrándose aumentos en la productividad de hasta 20% con el método óptimo.
Although workplace design and management are gaining more and more attention from modern organizations, workplace research is still very fragmented and spread across multiple disciplines in academia. ...There are several books on the market related to workplaces, facility management (FM), and corporate real estate management (CREM) disciplines, but few open up a theoretical and practical discussion across multiple theories from different fields of studies. Therefore, workplace researchers are not aware of all the angles from which workplace management and effects of workplace design on employees has been or could be studied. A lot of knowledge is lost between disciplines, and sadly, many insights do not reach workplace managers in practice. Therefore, this new book series is started by associate professor Rianne Appel-Meulenbroek (Eindhoven University of Technology, the Netherlands) and postdoc researcher Vitalija Danivska (Aalto University, Finland) as editors, published by Routledge. It is titled ‘Transdisciplinary Workplace Research and Management’ because it bundles important research insights from different disciplinary fields and shows its relevance for both academic workplace research and workplace management in practice. The books will address the complexity of the transdisciplinary angle necessary to solve ongoing workplace-related issues in practice, such as knowledge worker productivity, office use, and more strategic workplace management. In addition, the editors work towards further collaboration and integration of the necessary disciplines for further development of the workplace field in research and in practice. This book series is relevant for workplace experts both in academia and industry. This first book in the series focuses on the employee as a user of the work environment. The 21 theories discussed and applied to workplace design in this book address people’s ability to do their job and thrive in relation to the office workplace. Some focus more on explaining why people behave the way they do (the psychosocial environment), while others take the physical and/or digital workplace quality as a starting point to explain employee outcomes such as health, satisfaction, and performance. They all explain different aspects for achieving employee-workplace alignment (EWA) and thereby ensuring employee thriving. The final chapter describes a first step towards integrating these theories into an overall interdisciplinary framework for eventually developing a grand EWA theory. The Open Access version of this book, available at http://www.taylorfrancis.com/books/e/9781003128830, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
An effective method is a computational method that might, in principle, be executed by a human. In this paper, I argue that there are methods for computing that are not effective methods. The ...examples I consider are taken primarily from quantum computing, but these are only meant to be illustrative of a much wider class. Quantum inference and quantum parallelism involve steps that might be implemented in multiple physical systems, but cannot be implemented, or at least not at will, by an idealised human. Recognising that not all computational methods are effective methods is important for at least two reasons. First, it is needed to correctly state the results of Turing and other founders of computation theory. Turing is sometimes said to have offered a replacement for the informal notion of an effective method with the formal notion of a Turing machine. I argue that such a view only holds under limited circumstances. Second, not distinguishing between computational methods and effective methods can lead to mistakes when quantifying over the class of all possible computational methods. Such quantification is common in philosophy of mind in the context of thought experiments that explore the limits of computational functionalism. I argue that these ‘homuncular’ thought experiments should not be treated as valid.
Job rotation is an organisational strategy widely used in human-based production lines with the aim of preventing work-related musculoskeletal disorders (WMSDs). These work environments are ...characterised by the presence of a high repetition of movements, which is a major risk factor associated with WMSDs. This article presents a genetic algorithm to obtain rotation schedules aimed at preventing WMSDs in such environments. To do this, it combines the effectiveness of genetic algorithms optimisation with the ability to evaluate the presence of risk by repeated movements by following the OCRA ergonomic assessment method. The proposed algorithm can design solutions in which workers will switch jobs with high repeatability of movements with other less demanding jobs that support their recovery. In addition, these solutions are able to diversify the tasks performed by workers during the day, consider their disabilities and comply with restrictions arising from the work organisation.
Although workplace design and management are gaining more and more attention from modern organizations, workplace research is still very fragmented and spread across multiple disciplines in academia. ...There are several books on the market related to workplaces, facility management (FM), and corporate real estate management (CREM) disciplines, but few open up a theoretical and practical discussion across multiple theories from different disciplines. Therefore, workplace researchers are not aware of all the angles from which workplace management and effects of workplace design on employees has been or could be studied. A lot of knowledge is lost between disciplines, and sadly, many insights do not reach workplace managers in practice. Therefore, this new book series is started by associate professor Rianne Appel-Meulenbroek (Eindhoven University of Technology, the Netherlands) and postdoc researcher Vitalija Danivska (Aalto University, Finland) as editors, published by Routledge. It is titled ‘Transdisciplinary Workplace Research and Management’ because it bundles important research insights from different disciplinary fields and shows its relevance for both academic workplace research and workplace management in practice. The books will address the complexity of the transdisciplinary angle necessary to solve ongoing workplace-related issues in practice, such as knowledge worker productivity, office use, and more strategic management. In addition, the editors work towards further collaboration and integration of the necessary disciplines for further development of the workplace field in research and in practice. This book series is relevant for workplace experts both in academia and industry. This second book in the series focuses on the role of workplace management in the organization and the tasks that workplace management needs to consider. The 18 theories that are presented in this book and applied to workplace research discuss management aspects from the organization’s perspective or dive deeper into issues related to people and/or building management. They all emphasize that workplace management is a complex matter that requires more strategic attention in order to add value for various stakeholders. The final chapter of the book describes a first step towards integrating the presented theories into an interdisciplinary framework for developing a grand workplace management theory.
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