Academic and policy discourse has idealised academic mobility despite studies showing that it can have adverse effects on individuals’ experiences and contribute towards exacerbating existing ...inequalities. This article focuses on career (im)mobility stories of science, technology, engineering and mathematics (STEM) early career researchers that are variously sticky with emotion and affect. It places emphasis on the challenges, frictions and emotional tensions for early career researchers as part of this decision-making, irrespective of whether they decide to move or not. To do this, it deploys the concept of stickiness, which allows investigating the intersection and co-construction of embodied experiences of early career academics with the internationalisation discourse of academic excellence which are not often brought together. Focused on a largely under-examined population and context, it is based on a qualitative analysis of 15 in-depth interviews with a subsample of survey respondents, as part of a mixed methods study of Greek researchers in STEM. This article compares two groups of early career researchers who are seemingly at odds but have a lot in common: those with a highly international outlook moving to build an international profile and those who decide to stay and pursue research aspirations within a national context. Stickiness is demonstrated in two ways: stickiness to establishing an international profile and an academic career dictated by the internationalisation discourse; stickiness to affective considerations which are temporal, fluid and often understated. The main difference is how early career researchers address this stickiness: through the normative international mobility or participation in collaborative funding programmes. This article shows academic mobility is not only associated with benefits but can entail negative implications for individuals. It also provides empirical insights into hidden STEM early career researchers and elaborates a concept of stickiness in academic (im)mobility with discursive and affective layers, highlighting the importance of considering affect in career development scholarship.
Single cell analysis strives to probe molecular heterogeneity in morphologically similar cell populations through quantitative or qualitative measurements of genetic, proteomic, or metabolic ...products. Here, we applied mass analysis of single neurons to investigate cell–cell signaling peptides. The multiplicity of endogenous cell–cell signaling peptides is a common source of chemical diversity among cell populations. Certain peptides can undergo post-translational isomerization of select residues, which has important physiological consequences. The limited number of single cell analysis techniques that are sensitive to peptide stereochemistry make it challenging to study isomerization at the individual cell level. We performed capillary electrophoresis (CE) with mass spectrometry (MS) detection to characterize the peptide content of single cells. Using complementary trapped ion mobility spectrometry (TIMS) separations, we measured the stereochemical configurations of three neuropeptide gene products derived from the pleurin precursor in individual neurons (N = 3) isolated from the central nervous system of Aplysia californica. An analysis of the resultant mobility profiles indicated >98% of the detectable pleurin-derived peptides exist as the nonisomerized, all-l forms in individual neuron cell bodies. However, we observed 44% of the Plrn2 peptide from the pleurin precursor was present as the isomerized, d-residue-containing form in the nerve tissue. These findings demonstrate an unusual distribution of isomerized peptides in A. californica and establish CE–TIMS MS as a powerful analytical tool for investigating peptide stereochemistry at the single cell level.
This article explores the patterning of student im/mobility internally within the United Kingdom, using exceptionally detailed student records data on full-time undergraduate entrants from 2014. For ...this cohort of students, geographic mobility was clearly the preserve of the most socio-economically advantaged, and was less common for Pakistani and Bangladeshi ethnic groups. Significantly, the student's 'home' region emerges as the most important factor driving im/mobility even when social, ethnic and educational differences are held constant. The concept 'structures of feeling' can help make sense of immobility in areas of the North-East, North-West and Wales, where students are likely to look on higher education choice through a different lens of accumulated and contemporary, inter-generational cultural experience. Exploring exceptions to the dominant trends, we also find a more complex patterning of im/mobility that is likely to reflect the deep historical and structural framing of young people's socio-spatial horizons.
Building on emerging research into intergenerational contextual mobility, I use longitudinal data from France (1990–2008) to investigate the extent to which second-generation immigrants and the ...French majority continue to live in similar neighborhood environments during childhood and adulthood. To explore the persistence of ethnoracial segregation and spatial disadvantage, I draw on two measures of neighborhood composition: the immigrant share and the unemployment rate. The analysis explores the individual and contextual factors underpinning intergenerational contextual mobility and variation across immigrant-origin groups. The results document a strong stability of neighborhood environments from childhood to adulthood, especially with regard to the ethnoracial composition of the neighborhood. Individual-level factors are quite weak in accounting for these patterns compared with the characteristics of the city of origin. Moreover, the degree of contextual mobility between childhood and adulthood varies across groups. I find that neighborhood environments are more stable over time for non-European second-generation immigrants. The findings offer important new empirical contributions to the French literature on the residential segregation of immigrants and will more broadly be of interest to scholars of intergenerational spatial and social mobility.
The article presents the idea of modeling the decision-making process in the field of the metropolitan areas transport system. Due to the increasing process of metropolization and urbanization, which ...is predicted to be 68.4% worldwide and 83.7% in Europe in 2050, the issue will be even more sophisticated. The problem of depletion of transport network capacity as well as the implementation of modern technology solutions forces metropolitan committees to apply tools for metropolitan passenger transport system optimization. Significantly, the policy and regulations on sustainable urban mobility management are based on the mobility demand predictions and understanding of the travel decision-making process of citizens. The scientific purpose of this article is to build a mathematical model, as a tool supporting the multi-criteria decision-making process regarding the choice of means of transport in a developing metropolis. The issue raised in this article considers the most important research areas of the metropolitan transport means selection, which includes transport safety, qualitative, financial, and ecological aspects. The model was implemented in Silesian Metropolis in Poland with a particular emphasis on sharing mobility transport means users. As a result, a ranking of sharing transport means was developed, which is a piece of significant information for planners and future investors in the development of the metropolitan transport system.
Previous ion mobility (IM) studies have demonstrated that varying the drift gas composition can be used to enhance chemical selectivity and resolution, yet there are few drift gas studies aimed at ...achieving quantitatively reproducible mobility measurements. Here, we critically evaluate the conditions necessary to achieve reproducible collision cross section (CCS) measurements in pure drift gases (helium, nitrogen, argon, and carbon dioxide) using a commercial uniform field drift tube instrument. Optimal experimental parameters are assessed based on the convergence of CCS measurements to reproducible values which are compared with literature values. A suite of calibration standards with diverse masses, biological classes, and charge states are examined to assess chemical selectivity and resolution achievable in each drift gas. Results indicate nitrogen and argon perform similarly and are sufficient for most applications where high resolving power and high peak capacity are desired. Carbon dioxide exhibits more selectivity for resolving structurally heterogeneous compounds, which may be preferable in specific analyte pair separations. Helium demonstrated modest separation capabilities but has utility for comparison to theoretical values and previously published work. In drift gases other than nitrogen, pressure differentials up to 230 mTorr between the drift tube and upstream chamber were optimal for improving correlation to literature values, while in nitrogen, the recommended pressure differential of 150 mTorr was found appropriate. We present recommended experimental parameters as well as gas-specific CCS measurements for structurally homogeneous sets of analytes which are suitable for use by other laboratories as standards for purposes of instrument calibration and overall assessment of IM separation performance.
•We develop a new understanding of the effects of mobility on innovation by linking the economic systems literature to mobility.•We focus on a new, dynamically growing industry, the video games ...industry, for which so far no research on mobility patterns exists.•We show that the effect of inter-firm mobility on innovation is different between the top performers Japan and the US.
Open labour markets are often seen as a precondition for innovation, particularly for new industries. However, this view ignores two core findings of the economic systems literature: first, that mobility patterns are institutional microsystems that need to be complementary to other institutions in the labour market; and second, that new industries may be characterised by incremental and complex innovation. Based on these considerations, we ask how mobility affects innovation in the video games industry in the US and Japan. We find that inter-firm mobility is beneficial for innovation in the US, but has negative effects in Japan. We further find that inter-functional mobility is beneficial for innovation in both countries. Our analysis is based on career histories from the video games industry in the US and Japan. We present an empirical study based on the game development of 815 video games and the careers of 28,426 video game developers who were involved in the development of games released between 1999 and 2009.
The environmental instability of single‐ or few‐layer black phosphorus (BP) has become a major hurdle for BP‐based devices. The degradation mechanism remains unclear and finding ways to protect BP ...from degradation is still highly challenging. Based on ab initio electronic structure calculations and molecular dynamics simulations, a three‐step picture on the ambient degradation of BP is provided: generation of superoxide under light, dissociation of the superoxide, and eventual breakdown under the action of water. The well‐matched band gap and band‐edge positions for the redox potential accelerates the degradation of thinner BP. Furthermore, it was found that the formation of P‐O‐P bonds can greatly stabilize the BP framework. A possible protection strategy using a fully oxidized BP layer as the native capping is thus proposed. Such a fully oxidization layer can resist corrosion from water and leave the BP underneath intact with simultaneous high hole mobility.
Protected by native oxide: A three‐step picture of the ambient degradation of black phosphorus (BP) is given. A possible protection strategy using a fully oxidized BP layer as the capping is proposed. Such a fully oxidized layer can resist corrosion from water and leave the BP underneath intact with simultaneous high hole mobility.
Health disparities by socioeconomic status (SES) have been extensively documented, but less is known about the physical health implications of achieving upward mobility. This article critically ...reviews the evolving literature in this area, concluding that upward mobility is associated with a trade-off, whereby economic success and positive mental health in adulthood can come at the expense of physical health, a pattern termed skin-deep resilience. We consider explanations for this phenomenon, including prolonged high striving, competing demands between the environments upwardly mobile individuals seek to enter and their environments of origin, cultural mismatches between adaptive strategies from their childhood environments and those that are valued in higher-SES environments, and the sense of alienation, lack of belonging, and discrimination that upwardly mobile individuals face as they move into spaces set up by and for high-SES groups. These stressors are hypothesized to lead to unhealthy behaviors and a dysregulation of biological systems, with implications for cardiometabolic health.
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