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•Mapping and monitoring of slow-moving landslides.•Remote Sensing, statistical and ground-based measurements have been combined.•Integration of Machine Learning and InSAR techniques ...for landslide risk assessment.
This paper describes a novel methodology where Machine Learning Algorithms (MLAs) have been integrated to assess the landslide risk for slow moving mass movements, processes whose intermittent activity makes challenging any risk analysis worldwide.
MLAs has been trained on datasets including Interferometric Synthetic Aperture Radar (InSAR) and additional remote sensing datasets such as aerial stereo photographs and LiDAR and tested in the Termini-Nerano landslides system (southern Apennines, Italy).
The availability of such a wealth of materials allows also an unprecedented spatio-temporal reconstruction of the volume and the kinematic of the landslides system through which we could generate and validate the hazard map.
Our analysis identifies fifteen slow-moving phenomena, traceable since 1955, whose total area amounts to 4.1 × 105 m2 and volume to ~1.4 × 106 m3. InSAR results prove that seven out of the fifteen slow-moving landslides are currently active and characterized by seasonal velocity patterns. These new insights on the dynamic of the landslides system have been selected as the main independent variables to train three MLAs (Artificial Neural Network, Generalized Boosting Model and Maximum Entropy) and derive the landslide hazard for the area. Finally, official population and buildings census data have been used to assess the landslide risk whose highest values are located in the crown area, south of Termini village, and nearby Nerano.
This new methodology provides a different landslide risk scenario compared to the existing official documents for the study area and overall new insights on how to develop landslide risk management strategies worldwide based on a better understanding of slope processes thanks to the latest satellite technologies available.
Abstract The Termini Online Hungarian–Hungarian Dictionary and Database describes the lexicon of the Hungarian language as spoken in the countries neighbouring Hungary. It is considered to be a ...general dictionary of present-day Hungarian. Each entry contains authentic example sentences to illustrate the use of the headword, making it possible to examine the special use of a word or construction in a grammatical and pragmatic context. The lexicographical database is edited online in eight countries. The editors of the dictionary are members of the Termini Hungarian Language Research Network. Online editing makes it possible for the dictionary to expand – even simultaneously – as a result of activity in eight countries. In the present study, the authors review the novelties and peculiarities of the dictionary in some detail, touching on the following topics: dictionary structure, IT support, database character, multimedia elements, and labelling system.
Graphene nanoribbons (GNRs) and nanographenes synthesized by on‐surface reactions using tailor‐made molecular precursors offer an ideal playground for a study of magnetism towards nano‐spintronics. ...Although the zigzag edge of GNRs has been known to host magnetism, the underlying metal substrates usually veil the edge‐induced Kondo effect. Here, we report the on‐surface synthesis of unprecedented, π‐extended 7‐armchair GNRs using 7‐bromo‐12‐(10‐bromoanthracen‐9‐yl)tetraphene as the precursor. Characterization by scanning tunneling microscopy/spectroscopy revealed unique rearrangement reactions leading to pentagon‐ or pentagon/heptagon‐incorporated, nonplanar zigzag termini, which demonstrated Kondo resonances even on bare Au(111). Density functional theory calculations indicate that the nonplanar structure significantly reduces the interaction between the zigzag terminus and the Au(111) surface, leading to a recovery of the spin localization of the zigzag edge. Such a distortion of planar GNR structures offers a degree of freedom to control the magnetism on metal substrates.
π‐Extended 7‐armchair graphene nanoribbon with unique termini structures was synthesized on Au(111) using 7‐bromo‐12‐(10‐bromoanthracen‐9‐yl)tetraphene as the precursor. A Kondo resonance was observed for termini with nonplanar zigzag edges even on a bare Au(111) surface. DFT calculations revealed that the recovery of the spin localization of the zigzag terminus resulted from its weak interaction with the Au(111) because of its nonplanar conformation.
Protein N‐ and C‐termini have specific biochemical properties and functions. They play vital roles in various biological processes, such as protein stability and localization. In addition, ...post‐translational modifications and proteolytic processing generate different proteoforms at protein termini. In recent years, terminomics has attracted significant attention, and numerous strategies have been developed to achieve high‐throughput and global terminomics analysis. This review summarizes the recent protein N‐termini and C‐termini enrichment methods and their application in different samples. We also look ahead further application of terminomics in profiling protease substrates and discovery of disease biomarkers and therapeutic targets.
Graphene nanoribbons with unique edge and termini structures were synthesized on an Au(111) surface using 7‐bromo‐12‐(10‐bromoanthracen‐9‐yl)tetraphene as the molecular precursor. The nonplanar ...zigzag termini demonstrated Kondo resonance even on bare Au(111), as reported by Atsushi Ishikawa, Akimitsu Narita, Shigeki Kawai and co‐workers in their Research Article (e202302534).
Herein, we introduced ortho-phthalaldehyde (OPA) for blocking free amino groups and established a simple and robust method for comprehensive profiling of protein terminome based on strong cation ...exchange chromatography (SCX) fractionation. With the highly efficient and chemoseletive amine-group blocking, we identified 2271 canonical human protein N-termini, 1650 canonical human protein C-termini, as well as 645 protein neo-N-termini from HeLa cells.
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•Introduce highly efficient and chemoselective blocking of free amino group by OPA for protein terminome profiling.•Simultaneously analyze protein N-termini, C-termini, and neo-N-termini for comprehensive analysis of protein terminome.•Enable more robust results and reduced false positive results in the identification of neo-N-termini.
N-myristoylation is one of the most widespread and important lipidation in eukaryotes and some prokaryotes, which is formed by covalently attaching various fatty acids (predominantly myristic acid ...C14:0) to the N-terminal glycine of proteins. Disorder of N-myristoylation is critically implicated in numerous physiological and pathological processes. Here, we presented a method for purification and comprehensive characterization of endogenous, intact N-glycine lipid-acylated peptides, which combined the negative selection method for N-terminome and the nanographite fluoride-based solid-phase extraction method (NeS-nGF SPE). After optimizing experimental conditions, we conducted the first global profiling of the endogenous and heterogeneous modification states for N-terminal glycine, pinpointing the precise sites and their associated lipid moieties. Totally, we obtained 76 N-glycine lipid-acylated peptides, including 51 peptides with myristate (C14:0), 10 with myristoleate (C14:1), 6 with tetradecadienoicate (C14:2), 5 with laurate (C12:0) and 4 with lauroleate (C12:1). Therefore, our proteomic methodology could significantly facilitate precise and in-depth analysis of the endogenous N-myristoylome and its heterogeneity.
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•This study presented a strategy, NeS-nGF SPE, to direct analysis of the intact N-myristoylated peptides in mammalian cells.•Both the modification site and its endogenously attached lipid composition was obtained simultaneously in one identification.•We conducted the first global profiling of the endogenous and heterogeneous modification states for N-terminal glycine.
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