Background
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally infiltrating, rarely metastasizing, soft tissue tumour. Due to its indistinct margins, local aggressive behaviour and high ...recurrence rate, the surgical approach is complex. Micrographic surgery and variants of this technique,
e.g.
Tubingen torte technique (TTT), should be considered as first-line treatment.
Objectives
To confirm that TTT is a safe and tissue-sparing technique, relative to theoretical wide local excision (WLE), for the same lesions, as recommended by the guidelines in the literature.
Materials and Methods
Seventeen patients with histologically confirmed DFSP, treated with TTT between September 2014 and February 2019, were retrospectively analysed. For each patient, the final TTT excision area was calculated and compared with the theoretical equivalent area based on WLE. The difference in area was calculated and presented as percentage difference of preserved healthy skin based on the two approaches.
Results
In our patients, the mean preoperative lesion size was 4.55 ± 5.34 cm
2
. The mean final total excised area was 17.73 ± 11.75 cm
2
for TTT and 53.65 ± 15.57 cm
2
for WLE. The amount of preserved healthy tissue using the micrographic technique was significant; 69.15% (95% CI: 62.95–75.36) of healthy tissue was preserved using TTT. No recurrence or metastases were observed in any of the patients after a median follow-up period of 38.00 ± 21 months.
Conclusion
In our experience, TTT remains a safe, effective and tissue-sparing treatment for DFSP patients, especially when it is essential to spare tissue and in challenging locations.
Die österreichische Küche ist weltbekannt für ihre Süßspeisen wie Kaiserschmarrn oder Sacher-Torte. Doch in Wien hat eine Österreicherin ausgerechnet mit Cupcakes Erfolg. Innerhalb von vier Jahren ...hat Renate Gruber ein kleines Kuchenimperium aufgebaut - mit mehreren Filialen, Backkursen, Backbüchern und fast 40.000 Facebook-Fans.
Austrian cuisine is world renowned for its sweet dishes such as Kaiserschmarrn or Sacher-Torte. But in Vienna an Austrian has success with cupcakes of all things Within four years Renate Gruber has built up a small cake empire - with several branches, baking courses, baking books and nearly 40,000 Facebook fans.
Ochratoxin A is a typical cereal contaminant mainly produced by Aspergillus and Penicillium. With the aim to estimate the quantity of ochratoxin A that can be uptaken by a child, samples present in ...the diet of nursery school babies (age 12-36 months) and primary school children (age 6-10 years) were monitored in Milan. Cereal based foods (bread, pasta, pizza, cakes etc.) were daily collected and weekly pooled for 5 weeks in May and June 2004, for babies and children, respectively. Cereals were both from organic (nursery and primary schools) and conventional (primary schools) agriculture. The analysis of ochratoxin A was performed by high performance liquid chromatography with fluorescence detector and detection limit was 0.020 microng/kg. Ochratoxin A was found in all samples (100%) and the average concentrations were 0.048 microng/kg for nursery school and 0.161 microng/kg for primary school samples. The calculated expositions were 0.0008 microng/kg bw/day for babies and 0.0017 microng/kg bw/day for children and resulted 16 and 35%, respectively, of the UE-SCF TD1 (0.005 microng/kg bw/day)
L'ocratossina A è un contaminante tipico dei cereali prodotta da funghi del genere Aspergillus e Penicillium. Per valutare l'esposizione dei bambini a questa micotossina è stata condotta un'indagine sulla presenza di ocratossina A negli alimenti a base di cereali destinati ai bambini degli asili nido (12-36 mesi) e delle scuole elementari (6-10 anni) di Milano. I pasti a base di cereali (pane, pasta, pizza, torte ecc.) sono stati prelevati giornalmente da un centro di cottura ed utilizzati per l'allestimento di un pool settimanale. La raccolta dei campioni si è protratta per 5 settimane nel maggio-giugno 2004. I cereali utilizzati per la preparazione dei pasti erano totalmente biologici per l'asilo nido, mentre erano sia biologici, sia convenzionali per le scuole. Le analisi dei campioni sono state effettuate in HPLC con rilevatore fluorimetrico e il limite di rilevabilità del metodo era 0,020 microng/kg e quello di quantificazione era 0,050 microng/kg. L'ocratossina A è stata rilevata nel 100% dei campioni, con una concentrazione media di 0,048 microng/kg nei campioni dell'asilo nido e di 0,161 microng/kg in quelli delle scuole elementari, quindi l'esposizione all'OTA era pari a 0,0008 microng/kg pc/giorno per i bambini dell'asilo nido e 0,0017 microng/kg pc/giorno per quelli delle scuole elementari. Questi valori erano rispettivamente il 16 e il 35% del TDI indicato dall'UE-SCF (0,005 microng/kg pc/giorno)
