Xerosis, characterized by dry skin, is a frequent manifestation in patients undergoing maintenance hemodialysis. Understanding the prevalence of xerosis in this population and exploring its ...associations with various clinical and laboratory parameters is crucial for comprehensive patient care. The present study aimed to estimate the prevalence of xerosis in patients undergoing maintenance hemodialysis and to investigate the association between xerosis and various clinical and laboratory parameters, with a specific focus on serum copeptin as a surrogate for antidiuretic hormone. Methods. This cross-sectional observational study was conducted at the Hemodialysis Clinic of the Basrah Nephrology and Transplantation Center from March 1, 2022, to September 1, 2022. The prevalence of xerosis and its correlation with clinical characteristics and serum copeptin status were analyzed. Results. The study findings indicate that among the 48 patients undergoing maintenance hemodialysis, with an average age of 59.8 ± 8.8 years, 60.4% presented with xerosis. Serum copeptin levels, measuring 3.8 ± 2 ng/mL, showed a significant association with diuretic usage and serum parathyroid hormone (PTH) (p < 0.001 and p = 0.031, respectively). Notably, no correlations were observed with other demographic or laboratory parameters, despite the tendency of serum copeptin levels to be higher in females and patients with low serum albumin and PTH concentrations. Conclusions. In summary, xerosis was prevalent in 60.4% of patients undergoing maintenance hemodialysis and demonstrated a positive correlation with diuretic use and serum PTH levels.
Topical urea in skincare: A review Celleno, Leonardo
Dermatologic therapy,
November/December 2018, 2018-11-00, 20181101, Letnik:
31, Številka:
6
Journal Article
Recenzirano
Odprti dostop
Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, ...plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Here, we summarize the available clinical evidence regarding the effects of urea in the maintenance of healthy skin and management of skin disorders. At lower doses (≤10%), urea‐containing topical formulations act as a skin moisturizer, while at higher concentrations (>10% urea), urea‐based preparations exert a keratolytic action. Urea is also useful in combination therapies with anti‐inflammatory and anti‐fungal drugs, due to its activity as a penetration enhancer.
•Enhance transdermal drug delivery was achieved via microneedle administration.•Light responsive microneedles were designed upon iron (III) to iron (II) shift.•Long-term curative effect reduced ...annoying repeated administration.•The ICAMP system was comparable to lotion or cream for xerosis treatment.
Dry skin, known as the xerosis, would induce deep cracks and fissures, leading to bleeding and increased risk of allergens and pathogens penetrating the skin, which may trigger allergic and irritant contact dermatitis as well as the severe infection. High-frequent administration of traditional emulsion or moisturizer often results in significantly reduced patient compliance/adherence and limited therapeutic efficacy. Microneedle (MN) patches have been extensively investigated due to their deep penetration through the epidermis for sustained release in a patient-friendly manner. In this study, an iron (III) cross-linked alginate microneedle patch (ICAMP) has been developed for long-term treatment of xerosis by delivering the ammonium lactate for local management. In order to achieve on-demand treatment, the microneedles were cross-linked with iron (III) which could be photodegraded into iron (II) by exposure to light at 405 nm, triggering microneedles to dissolve in the interstitial fluid for payload release. In such a way, the drug could be released in a well-tunable fashion by using a light-based controller, suggesting a regulated manner to treat xerosis especially under intense light radiation.
The stratum corneum is the outermost layer of the epidermis. It acts as an interface with the external environment and functions as a barrier that prevents microorganisms and allergens from ...penetrating the skin, while preventing bodily fluids, electrolytes and proteins from being lost in a process aimed at maintaining homeostasis. With the novel coronavirus disease 2019 (COVID-19) outbreak, there has been an increase in hygiene practice, particularly hand washing and the use of hand sanitisers. These practices have undoubtedly assisted a great deal in combatting the rate of transmission and contributed immensely to saving lives. However, repeated hand washing and the use of sanitisers have both been linked with marked skin dryness and contact dermatitis. This especially holds true when the abovementioned practices are carried out in the absence of intermittent hand moisturiser usage.
Antibacterial activity of plants is a subject of interest in the search for new antibiotics and fungicidal preparations. This article analyzes the effectiveness of the action of extracts of plants on ...microorganisms: six species of bacteria (Salmonella typhimurium, Listeria monocytogenes, Escherichia coli, Klebsiella pneumoniae, Corynebacterium xerosis, Proteus vulgaris) and one fungus (Candida albicans). For the assay, we used herbal material of 50 species (seeds, grass, shoots, leaves, compound fruit, peel) obtained at different periods of the growing season.
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