Univerzitetna knjižnica Maribor (UKM)
Knjižnica je med tednom odprta od 8. do 14. ure, ob sredah do 17. ure ter ob sobotah od 9. do 13. ure. Čitalnica ČUK je odprta od ponedeljka do sobote od 12. do 24. ure, ob nedeljah je zaprta. Informacije: 02 25 07 431, ukm@um.si
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Modulating CD4+ T cell migration in the postischemic liver : hepatic stellate cells as new therapeutic target?Reifart, Jorg ...BACKGROUND: CD4+ T cells play a critical role during hepatic ischemia-reperfusion (I/R) injury although the mechanisms of their migration in the postischemic liver remain unclear. We answered the ... questions of whether hepatic stellate cells (HSCs) interact with CD4+ T cells during I/R of the liver and whether modulation of HSC activity affects T cell-dependent I/R injury. METHODS: In mice, migration of CD4+ T cells was analyzed in vivo using conventional intravital microscopy and two-photon microscopy. CD4+ T cell-HSC interactions were visualized after infusion of fluorescence-labeled CD4+ T cells into Cx3CR1 mice (mice exhibiting GFP-labeled HSCs) after I/R. Because the activation of HSC is controlled by endocannabinoid receptors, CB-1 and CB-2, the mice received treatment before I/R with the CB-2 agonist JWH-133 to reach HSC depletion or the CB-1 agonist arachidonylcyclopropylamide to activate HSCs. Sinusoidal perfusion and liver transaminases were used as markers of I/R injury. RESULTS: Hepatic I/R induced CD4+ T cell recruitment in sinusoids. More than 25% of adherent CD4+ T cells were colocalized with HSCs during reperfusion, suggesting a direct cell-cell interaction. The HSC deactivation with JWH-133 significantly attenuated the CD4+ T cell recruitment in the postischemic liver and reduced I/R injury as compared to the vehicle-treated group. The HSC hyperactivation by CB-1, however, did not affect T-cell migration and even increased perfusion failure. CONCLUSION: Our in vivo data suggest that CD4+ T cells interact with HSCs on their migration into the hepatic parenchyma, and a depletion or deactivation of HSCs protects the liver from T cell-dependent I/R injury.Vir: Transplantation. - ISSN 0041-1337 (Vol. 99, no. 1, jan. 2015, str. 41-47)Vrsta gradiva - članek, sestavni delLeto - 2015Jezik - angleškiCOBISS.SI-ID - 81792001
Avtor
Reifart, Jorg |
Rentsch, Markus |
Coletti, Raffaele |
Sobočan, Monika |
Thasler, Wolfgang |
Khandoga, Andrej
Teme
nefrologija |
bolezni ledvic |
hepatitis
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Reifart, Jorg | ![]() |
Rentsch, Markus | ![]() |
Coletti, Raffaele | ![]() |
Sobočan, Monika | 50187 |
Thasler, Wolfgang | ![]() |
Khandoga, Andrej | ![]() |
Vir: Osebne bibliografije
in: SICRIS
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