Študij mediatorskih sistemov v humanem miometriju : doktorska disertacija
Novak-Antolič, Živa
The nature of the enormous increase of myometrial responsiveness observed at parturition compared to the low responsiveness during pregnancy is still poorly understood. The changes involved with the ...phenomenon occur at several levelsČ in the ratios of circulating estrogenžprogesterone levels and in the concentration of different hormone receptors on the myometrial cell membrane. Furthermore, the morphologic changes occur within the myocardial cells and in uterine innervation. Compared to other systems, there are relatively few data in the literature on the detailed role and behaviour of the components of the cholinergic system in the pregnant and parturient human uterus. Consequently, we decided to evaluate two components of the cholinergic system in the controlgroup, where the labour process has not yet started, and in the study group, where labour was well advanced. In both groups either elective or urgent cesarean sections were performed, respectively, for maternal andžor fetal indications. Activity of cholinesterases in myometrium was significantlyhigher in the study group. In contrast to some previous reports, only traces of activity of cholineacetyltransferase were found in the myometrium of either group. The cholinergic innervation may still be functioning, but the muscležnerve mass-ratio is quite high in the pregnant myometrium near term and for such a dilute enzyme the assay method might not be sensitive enough. Cytochemically, the reaction products of the acetylcholinesterase and butyrylcholinesterase activities were found in the cell membrane, nuclear membrane and sarcoplasmic reticulum. No differences between the groups were found as far as subcellular localization of the reaction products is concerned. (Abstract truncated at 2000 characters).
Vrsta gradiva - disertacija
; neleposlovje za odrasle
Založništvo in izdelava - Ljubljana : [Ž. Novak Antolič], 1989
doktorske disertacije NOVAK-Antolič Živa Študij IN: 099000623
prosto - na dom, čas izposoje: 1 mes.
MF, Centralna medicinska knjižnica, Ljubljana
doktorske disertacije NOVAK-Antolič Živa Študij IN: 099000624
prosto - na dom, čas izposoje: 1 mes.
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