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Trofični učinki glijalnega rastnega dejavnika na dopaminergične nevrone substance nigre pri podganiŽižek, Metka, 1974-Absence of effective means for prevention or reversal of neurodegenerative processes that are a major element of morbidity in the elderly population are a constant insentive for research of new ... treatment options. Among other strategies, intraparenchymal administration of trophic substances into the diseased brain has already entered the stage of clinical safety trials. At thesame time, basic science still does not have sufficient insight into the mechanisms of action of these substances or their possible side effects. Thus the aim of this study has been to address some of the unknown issues related to glial cellderived neurotrophic factor, GDNF, that is already being tested in clinic. The study evaluated major effects of intraparenchymal administration of rat recombinant GDNF on the rat nigrostriatal connections invivo. Also, an excitotoxic injury of the parenchymum was employed to stimulate an increase in GDNF content and midterm effects of this procedure onthe rat nigrostiatal connections was studied. In the preliminary study, the optimal parameters for exogenous GDNF administration and for stimulating its local availability were determined, based on changes these procedures had on (1) the number of dopaminergic (Da) neurons in the selected region of the substantia nigra (SN), (2) the average area size of the Da neurons in the SN, and (3) the density of Da innervation of the striatum. In the subsequent study, the research focused on the number of Da neurons of the SN as the majorindicator of trofic effects of exogenous or endogenous GDNF. The study results showed that low dose rat recombinant (GDNF) administered into the infact rat nigrostriatal system has predominantly local effects, increasing the density of striatal Da innervation when administered intrastriatally and slightly increasing the number of Da neurons in the SN when administered perinigrally. (Abstract truncated at 2000 characters).Vrsta gradiva - magistrsko deloZaložništvo in izdelava - Ljubljana : [M. Žižek], 2002Jezik - slovenskiCOBISS.SI-ID - 2408468
Avtor
Žižek, Metka, 1974-
Drugi avtorji
Bresjanac, Mara
Teme
Rats |
Substantia nigra |
Secretion |
Dopamine |
Neuregulin-1 |
Therapeutic use |
Parkinson disease |
Therapy |
Podgane |
Substancia nigra |
Sekrecija |
Dopamin |
Neuregulin-1 |
Terapevtska raba |
Parkinsonova bolezen |
Terapija |
nevro-znanosti
Knjižnica | Signatura – lokacija, inventarna št. ... | Status izvoda |
---|---|---|
MF, Centralna medicinska knjižnica, Ljubljana | magistrske naloge ŽIŽEK Metka Trofični IN: 020020848 |
prosto - na dom, čas izposoje: 1 mes. |
Vnos na polico
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Žižek, Metka, 1974- | 20408 |
Bresjanac, Mara | 10428 |
Vir: Osebne bibliografije
in: SICRIS
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