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  • Quantification and modeling of nanomechanical properties of chlorpropamide [alpha], [beta], and [gamma] conformational polymorphs
    Janković, Biljana, 1982- ...
    The nanomechanical properties of the alpha, beta, and gamma conformational polymorphs of chlorpropamide were determined by the dynamic contact module continuous stiffness measurement at nanoindenter. ... The mechanical anisotropy of the alpha-polymorph was confirmed by indenting different faces, and its deformational behavior was assigned as ductile. Based on the nanoindentation results, the beta and gamma forms are moderately hard with plastic flow at contact points. The results revealed a correlation between Young's modulus and inter-planar interaction energy with regard to crystal orientation. Interpretation of the measurements was assisted by two- and three-dimensional periodic density functional theory (DFT) calculations, yielding inter-planar energies of polymorphs along the cell vectors and exhibiting a very good match with the experimental observations. The results suggest that the inter-planar interaction energy could serve as a first-order indicator for ranking the mechanical propensity of crystalline active ingredients. The study confirms the practical aspect of using the alpha form for preparing chlorpropamide tablets with a direct compression procedure due to its substantial level of ductility.
    Vir: European Journal of Pharmaceutical Sciences. - ISSN 0928-0987 (Vol. 110, 15. Dec. 2017, str. 109-116)
    Vrsta gradiva - članek, sestavni del
    Leto - 2017
    Jezik - angleški
    COBISS.SI-ID - 4439409

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0928098717303470

    Dostop preko Konzorcija UL


    DOI

vir: European Journal of Pharmaceutical Sciences. - ISSN 0928-0987 (Vol. 110, 15. Dec. 2017, str. 109-116)

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