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  • Vpliv povprečne koncentracije glukoze v dializni peritonealni raztopini na nekatere laboratorijske parametre = Influence of average glucose concentration in dialysis fluids used for peritoneal dialysis (CAPD) on clinical data
    Fazarinc, Franc
    Background. Depending on physician's prescription, patients on peritoneal dialysis (CAPD) use dialysate solutions with 1.5 to 4.5% of glucose. Thus, thedaily glucose load ranges from 120 to 540 g. ... During the first four hours following the instillation, approximately 60% of glucose in the dialysate is absorbed across the peritoneal membrane, resulting in a glucose load comparable to that of the oral glucose tolerance test. This may result not only in changes of peritoneal membrane finally leading to peritoneal fibrosis but also in changes of the whole organism exposed to hyperglicemia. Methods. In this retrospective study we tried to demonstrate the influence of average daily glucose concentration in dialysis fluids on dialysis adequacy (decided using method of Lundin), on ultrafiltration, on urea, creatinin, cholesterol, triglycerides, albumins, proteins, phosphorus (serum) and body weight. The patients were divided in two groups, i.e. in those in whom the average daily glucose concentration did not exceed 2.0% and the those with average glucose concentration equal or greater than 2.1%. A total of 20 patients (9 females and 11 males) with a mean age of 57.7 years were included in the study and followed 3-44 months. Results. When using dialysis fluids with average daily glucose concentration exceeding 2.0%, there where no statistically significantchanges in urea, creatinin, cholesterol, triglycerides, albumin or glucose concentration; however, asignificant increase of peritoneal ultrafiltration and total blood protein value was observed. Conclusions. It iswell known that higher ultrafiltration increases intraabdominal pressure, whereas higher glucose concentration affects peritoneal vasculate and mesothelium, which may lead to peritoneal fibrosis, and finally to treatment failure in CAPD. (Abstract truncated at 2000 characters.)
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Let. 66, št. 7-8, 1997, str. 383-386)
    Vrsta gradiva - članek, sestavni del
    Leto - 1997
    Jezik - slovenski
    COBISS.SI-ID - 6788057

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