-
Spatio-temporal modelling explains the effect of reduced plasma membrane ▫$Ca^{2+}$▫ efflux on intracellular ▫$Ca^{2+}$▫ oscillations in hepatocytesMarhl, Marko ...In many non-excitable eukaryotic cells, including hepatocytes, ▫$Ca^{2+}$▫ oscillations play a key role in intra- and intercellular signalling, thus regulating many cellular processes from ... fertilisation to death. Therefore, understanding the mechanisms underlying these oscillations, and consequently understanding how they may be regulated, is of great interest. In this paper, we study the influence of reduced ▫$Ca^{2+}$▫ plasma membrane efflux on ▫$Ca^{2+}$▫ oscillations in hepatocytes. Our previous experiments with carboxyeosin show that a reduced plasma membrane ▫$Ca^{2+}$▫ efflux increases the frequency of ▫$Ca^{2+}$▫ oscillations, but does not affect the duration of individual transients. This phenomenon can be best explained by taking into account not only the temporal,but also the spatial dynamics underlying the generation of ▫$Ca^{2+}$▫ oscillations in the cell. Here we divide the cell into a grid of elements and treat the ▫$Ca^{2+}$▫ dynamics as a spatio-temporal phenomenon. By converting an existing temporal model into a spatio-temporal one, we obtain theoretical predictions that are in much better agreement with the experimental observations.Vir: Journal of theoretical biology. - ISSN 0022-5193 (Vol. 252, iss. 3, 2008, str. 419-426)Vrsta gradiva - članek, sestavni delLeto - 2008Jezik - angleškiCOBISS.SI-ID - 16014344
Avtor
Marhl, Marko |
Gosak, Marko, 1982- |
Perc, Matjaž |
Dixon, C. Jane |
Green, Anne K.
Teme
celično signaliziranje |
kalcijeve oscilacije |
celične oscilacije |
prostorsko-časovna dinamika |
hepatociti |
stohastične simulacije |
cellular signalling |
calcium oscillations |
intracellular oscilations |
spatio-temporal dynamics |
hepatocytes |
stochastic simulations
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Marhl, Marko | 13159 |
Gosak, Marko, 1982- | 28405 |
Perc, Matjaž | 23428 |
Dixon, C. Jane | ![]() |
Green, Anne K. | ![]() |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.