Macro CK type 1 as a major component of serum creatine kinase activity in pregnant sheep
Vojtic, Igor
Electrophoretic separation of creatine (ATP: creatine phosphotransferase, E.C.2.7.3.2) isoenzymes in agarose gel was made in the serum of 93 sheep of three Slovenian domestic breeds (Solcavska, ...Pramenka and Bovska breeds). 44 sheep were pregnant between 112 and 135 days at the time of the blood collection. The median value of serum total CK activity for all animals investigated was 82 U/l. After direct immunoinhibition of CK with anti-M-CK with anti-M-CK monoclonal antibodies the total CK activity remained the same (88 U/l, P=0.354). There were significant differences among breeds in Ck activity for the Solcavska (101 U/l), Bovska (89 U/l) and Pramenka breeds (73 U/l), respectively (Kruskal-Wallis one way analysis of variance, P<0.01), and between pregnant (105 U/l) and non-pregnant animals (76 U/l), irrespective of the breed Mann-Whitney rank sum test, P<0.05). According to electrophoresis, all non-pregnant sheep had exclusively free CK-BB serum bands actvity. In all pregnant sheep coupled dimeric BB variant appeared as macro-CK type 1 in the range between 80% and 100% of total CK activity. The present study confirms the existence of an elimination mechanism for CK from the plasma abundance free CK-BB enzyme.
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