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Development of an experimental dead-end microfiltration layout and process repeatability analysisBombek, Gorazd ...Microfiltration is an important process in the pharmaceutical industry. Filter selection and validation is a time-consuming and expensive process. Quality by design approach is important for product ... safety. The article covers the instrumentalization and process control of a laboratory-scale dead-end microfiltration layout. The layout is a downscale model of the actual production line, and the goal is filter validation and analysis of process parameters, which may influence filter operation. Filter size, fluid pressure, valve plunger speed, and timing issues were considered. The focus is on the identification of the most influential process parameters and their influence on the repeatability of pressure oscillations caused by valve opening. The goal was to find the worst-case scenario regarding pressure oscillations and, consequently, filter energy intake. The layout was designed as compact as possible to reduce pressure losses between the filter and valve. Valve-induced pressure oscillations proved to be prevailing over the water hammer effect. Several filters in sizes between 3.5 cm2 and 6900 cm2 were tested, and some recommendations were suggested for the reduction of energy intake of the filter and to improve the repeatability of the process.Vir: Processes [Elektronski vir]. - ISSN 2227-9717 (Vol. 12, iss. 2, [article no.] 253, Jan. 2024, 19 str.)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 183408643
Avtor
Bombek, Gorazd |
Kevorkijan, Luka |
Hrovat, Grega, 1989- |
Kuzman, Drago |
Kapun, Aleks |
Ravnik, Jure |
Hriberšek, Matjaž |
Hribernik, Aleš, 1960-
Teme
filtracija |
nihanje tlaka |
ponovljivost |
postopki |
parametri |
filtration |
pressure oscillations |
repeatability |
processes |
parameters
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Avtor | Bombek, Gorazd ... |
Naslov | Development of an experimental dead-end microfiltration layout and process repeatability analysis |
Datum objave | 2024-01-24 |
COBISS.SI-ID | 183408643 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Raziskave v energetskem, procesnem in okoljskem inženirstvu | P2-0196-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
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vir: Processes [Elektronski vir]. - ISSN 2227-9717 (Vol. 12, iss. 2, [article no.] 253, Jan. 2024, 19 str.)
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Bombek, Gorazd | 19096 |
Kevorkijan, Luka | 54801 |
Hrovat, Grega, 1989- | ![]() |
Kuzman, Drago | 18355 |
Kapun, Aleks | ![]() |
Ravnik, Jure | 24331 |
Hriberšek, Matjaž | 11167 |
Hribernik, Aleš, 1960- | 05536 |
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