-
Učinek spojine LEK-8829 na dopaminskih receptorjih pri podgani z enostransko okvaro striatuma : doktorska disertacijaŠprah, LilijanaPrevious experiments have suggested a potential atypical antipsychotic activity of the ergoline derivative LEK-8829 (9,10-didehydro-N-methyl-(2-propynyl)-6-methyl-8-aminomethylergoline bimaleinate). ... Experiments in vitro showed a high affinity to 5-HT1A, 5-HT2 andD-2 receptors and a moderate affinity to D-1 receptors. The ratio of pKi values 5-HT2žD-2 was similar to the ratio of atypicat antipsychotic clozapine.In vivo experiments showed an antagonism of dopamine and serotonin receptor-linked behaviors of LEK-8829. By using animal models with supersensitive dopamine receptors it was also found that LEK-8829 is an antagonist of dopamine D-2 receptors and an agonist of dopsmine D-1 receptors in dopamine depleted striatum. The aim of thesis was to study the effects of LEK-8829 on movement and on gene expression within striatum in order to determine its effects on dopaminergic transmission. It was hypothesized that LEK-8829 simultaneously stimulates and blocks dopsminergic transmission via dopamine D-1 and D-2 receptors, respectively. Rats with unilateral striatat lesions with ibotenic acid (IA) represent an animal model with normosensitive dopamine receptors that is appropriate for the studies of the effects of dopaminergic drugs on locomotor activity. In this model, IA destroys dopaminoceptive striatal efferent neurons. The locomotor etfects of dopaminergie drugs are therefore thought to bo conveyed by the normosensitive dopamine receptors of the intact side. For example, turning toward the lesioned side (ipsilateral turning) is induced when dopamine D-1 and D-2 receptors on the intact side are directly or indirectly eostimulated by apomorphine or by amphetamine. The IA-lesioned rats displayed intensive ipsilateral turning when challenged with either apomorphine or amphetamine. (Abstract truncated at 2000 characters.)Vrsta gradiva - disertacija ; neleposlovje za odrasleZaložništvo in izdelava - Ljubljana : [L. Šprah], 1999Jezik - slovenskiCOBISS.SI-ID - 2094356
Avtor
Šprah, Lilijana
Drugi avtorji
Sket, Dušan
Teme
Ergolines |
Analogs and derivates |
Ergolines |
Pharmacology |
Receptors, dopamine |
Drug effects |
Corpus striatum |
Drug effects |
Ergolini |
Analogi in derivati |
Ergolini |
Farmakologija |
Receptorji dopaminski |
Učinki zdravil |
Korpus striatum |
Učinki zdravil
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Knjižnica | Signatura – lokacija, inventarna št. ... | Status izvoda |
---|---|---|
Univerzitetna knjižnica Maribor | Skladišče II 49137 | prosto - za čitalnico |
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Šprah, Lilijana | 15883 |
Sket, Dušan | 01086 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.