Vpliv antiglavkomske terapije na izražanje antigenov HLA-DR na epitelijskih celicah veznice : doktorska naloga = The influence of antiglaucoma therapy on the expression of HLA-DR antigens on conjunctival epithelial cells : doctoral thesis
Cvenkel, Barbara
Purpose: To analyse the expression of inflammatory markers HLA-DR on conjunctival epithelial cells in patients taking topical antiglaucoma therapy. Methods: The impression cytology specimens were ...obtained from 10 patients taking no topical medication and from 39 patients with uncontrolled glaucoma referred for filtration surgery. In none of the patients was an ocular surface inflammation present as evaluated by slit lamp examination, tear break up time, and Schirmer's test. The specimens were collected preoperatively, 3 months, and 6 months after surgery. The expression of HLA-DRon T lymphocytes and epitheliai cells was analysed by flow cytometry. Results: A significant increase in the level of HLA-DR fluorescence on epithelial cells was found preoperatively in patients with glaucoma compared to control group (P = 0,002). Antiglaucoma therapy for three months or more with at least two topical medications induced significant subclinical inflammation which persisted regardless of the duration of therapy. The increased percentage of HLA-DR positive epithelial cells and T lymphocytes in the control group (P = 0,006 and P = 0,01) mainly reflected the greater numberof collected cells, and not the level of inflammation. A significant increased expression of HLA-DR on T lymphocytes was detected 3 months after surgery (P = 0,04). Higher percentage and fluorescence intensity of reactive T lymphocytes was associated with higher percentage and fluorescence intensity of reactive epithelial cells three months after surgery. Six months after surgery the level of HLA-DR fluorescence on epithelial cells and T lymphocytesdecreased but remained elevated versus preoperative levels. (Abstract truncated at 2000 characters)
Vrsta gradiva - disertacija
; neleposlovje za odrasle
Založništvo in izdelava - Ljubljana : [B. Cvenkel], 2001
Bibliografsko gradivo je bilo uspešno dodano na polico.
Dodajanje bibliografskega gradiva na polico ni uspelo.
Gradivo je že na polici.
Trajna povezava
URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto
Faktor vpliva
Izdaja
Kategorija
Razvrstitev
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Izberite knjižnično izkaznico:
Baze podatkov,
v katerih je revija indeksirana
Ime baze podatkov
Področje
Leto
Povezave do osebnih bibliografij avtorjev
Povezave do podatkov o raziskovalcih v sistemu SICRIS
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Citiranje
Funkcionalnost trenutno ni na voljo. Prosimo, poskusite kasneje.
