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  • Fecal calprotectin as a marker of severity of mucosal involvement in children inflammatory bowel disease
    Rižnik, Petra ...
    Introduction: Inflammatory bowel disease (IBD) in children has a remittent course with episodes of remission and relapses. Aim: The aim of our study was to evaluate the value of fecal calprotectin ... (FC), C-reactive protein (CRP) and clinical scores in prediction of endoscopic and histological lesions in children with IBD treated at Pediatric Department of University Medical Centre Maribor. Material and methodology: 28 children with IBD confirmed according to Porto criteria (15 with ulcerative colitis (UC), 13 with Crohn%s disease (CD); mean age 14.2 years) were included in the study. We retrospectively reviewed clinical scores (PUCAI, PCDAI), CRP values, endoscopic and histological data as well as FC values in all included children. Correlation of observed parameters was analyzed using SPSS for Windows. Results: In children with UC the correlation between histological lesion and FC (r=0.713, p=<0.01), CRP (r=0,446; n.s.) or PUCAI (r=0.567, p=<0.05) was higher in comparison to CD (FC r=0.429, n.s.; CRP r=0.431, n.s.; PCDAI r=0.185, n.s.). Similar was found for correlation of endoscopy scores with same parameters (UC: FC r=0.601, p<0.05; CRP: r=0.334, n.s.; PUCAI: r=0.342, n.s.; CD: FC r=0.417, n.s.; CRP r=0.221, n.s.; PCDAI r=0.180, n.s.). Conclusion: A better prediction of the severity of endoscopic and histological lesions can be achieved by determination of FC compared to CRP and disease activity scores, especially for UC. FC as a noninvasive marker could possibly be used to reduce the number of endoscopic procedures in children with confirmed diagnosis of IBD.
    Vir: Abstract book 2014 (Str. 75)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 83582209

    Povezava(-e):

    http://www.imscns.com/assets/uploads/abstract/Abstract%20Book%20Web%20BW.pdf

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