E-viri
Recenzirano
Odprti dostop
-
Seiler, Michael; Yoshimi, Akihide; Darman, Rachel; Chan, Betty; Keaney, Gregg; Thomas, Michael; Agrawal, Anant A; Caleb, Benjamin; Csibi, Alfredo; Sean, Eckley; Fekkes, Peter; Karr, Craig; Klimek, Virginia; Lai, George; Lee, Linda; Kumar, Pavan; Lee, Stanley Chun-Wei; Liu, Xiang; Mackenzie, Crystal; Meeske, Carol; Mizui, Yoshiharu; Padron, Eric; Park, Eunice; Pazolli, Ermira; Peng, Shouyong; Prajapati, Sudeep; Taylor, Justin; Teng, Teng; Wang, John; Warmuth, Markus; Yao, Huilan; Yu, Lihua; Zhu, Ping; Abdel-Wahab, Omar; Smith, Peter G; Buonamici, Silvia
Nature medicine, 04/2018, Letnik: 24, Številka: 4Journal Article
Genomic analyses of cancer have identified recurrent point mutations in the RNA splicing factor-encoding genes SF3B1, U2AF1, and SRSF2 that confer an alteration of function. Cancer cells bearing these mutations are preferentially dependent on wild-type (WT) spliceosome function, but clinically relevant means to therapeutically target the spliceosome do not currently exist. Here we describe an orally available modulator of the SF3b complex, H3B-8800, which potently and preferentially kills spliceosome-mutant epithelial and hematologic tumor cells. These killing effects of H3B-8800 are due to its direct interaction with the SF3b complex, as evidenced by loss of H3B-8800 activity in drug-resistant cells bearing mutations in genes encoding SF3b components. Although H3B-8800 modulates WT and mutant spliceosome activity, the preferential killing of spliceosome-mutant cells is due to retention of short, GC-rich introns, which are enriched for genes encoding spliceosome components. These data demonstrate the therapeutic potential of splicing modulation in spliceosome-mutant cancers.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.