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Balibar, Carl J; Klein, Daniel J; Zamlynny, Beata; Diamond, Tracy L; Fang, Zhiyu; Cheney, Carol A; Kristoff, Jan; Lu, Meiqing; Bukhtiyarova, Marina; Ou, Yangsi; Xu, Min; Ba, Lei; Carroll, Steven S; El Marrouni, Abdellatif; Fay, John F; Forster, Ashley; Goh, Shih Lin; Gu, Meigang; Krosky, Daniel; Rosenbloom, Daniel I S; Sheth, Payal; Wang, Deping; Wu, Guoxin; Zebisch, Matthias; Zhao, Tian; Zuck, Paul; Grobler, Jay; Hazuda, Daria J; Howell, Bonnie J; Converso, Antonella
Science translational medicine, 02/2023, Letnik: 15, Številka: 684Journal Article
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host genome. Reservoir reduction is therefore an important HIV-1 cure strategy. Some HIV-1 nonnucleoside reverse transcriptase inhibitors induce HIV-1 selective cytotoxicity in vitro but require concentrations far exceeding approved dosages. Focusing on this secondary activity, we found bifunctional compounds with HIV-1-infected cell kill potency at clinically achievable concentrations. These targeted activator of cell kill (TACK) molecules bind the reverse transcriptase-p66 domain of monomeric Gag-Pol and act as allosteric modulators to accelerate dimerization, resulting in HIV-1 cell death through premature intracellular viral protease activation. TACK molecules retain potent antiviral activity and selectively eliminate infected CD4 T cells isolated from people living with HIV-1, supporting an immune-independent clearance strategy.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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