Medicine and physicians in Dubrovnik during the last two centuries, i.e. in the period after the dissolution of the Republic of Dubrovnik by Napoleon's Army, have attracted less interest among medical historians. In this paper, the lives and medical careers of two physicians from Dubrovnik, father and son, Baldo and Ante Bibica, have been reconstructed from the end of the nineteenth and the first half of the twentieth century by searching through the contemporary medical journals and newspapers as well as private archives of the members of family Bibica. Baldo Bibica graduated medicine in Vienna and spent the whole professional life as a municipal physician, at first, in the places in the vicinity of Dubrovnik and from 1903 in Gruž. Ante Bibica studied medicine in Graz and in Zagreb to become the first person from Dubrovnik promoted at the School of Medicine, Zagreb University. He specialized in dermatovenereology in Vienna and worked, as a specialist, in Dubrovnik. They both were active in the professional medical societies (at local and national levels) and were influential in the social life in Dubrovnik.