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Park, Jong-Eun; Botting, Rachel A; Domínguez Conde, Cecilia; Popescu, Dorin-Mirel; Lavaert, Marieke; Kunz, Daniel J; Goh, Issac; Stephenson, Emily; Ragazzini, Roberta; Tuck, Elizabeth; Wilbrey-Clark, Anna; Roberts, Kenny; Kedlian, Veronika R; Ferdinand, John R; He, Xiaoling; Webb, Simone; Maunder, Daniel; Vandamme, Niels; Mahbubani, Krishnaa T; Polanski, Krzysztof; Mamanova, Lira; Bolt, Liam; Crossland, David; de Rita, Fabrizio; Fuller, Andrew; Filby, Andrew; Reynolds, Gary; Dixon, David; Saeb-Parsy, Kourosh; Lisgo, Steven; Henderson, Deborah; Vento-Tormo, Roser; Bayraktar, Omer A; Barker, Roger A; Meyer, Kerstin B; Saeys, Yvan; Bonfanti, Paola; Behjati, Sam; Clatworthy, Menna R; Taghon, Tom; Haniffa, Muzlifah; Teichmann, Sarah A
Science (American Association for the Advancement of Science), 02/2020, Letnik: 367, Številka: 6480Journal Article
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8αα T cell populations, thymic fibroblast subtypes, and activated dendritic cell states. In addition, we reveal a bias in TCR recombination and selection, which is attributed to genomic position and the kinetics of lineage commitment. Taken together, our data provide a comprehensive atlas of the human thymus across the life span with new insights into human T cell development.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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