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Liu, Shuai; Huang, Yangen; Qing, Feng-Ling; Xu, Xiu-Hua
Organic letters, 09/2018, Letnik: 20, Številka: 17Journal Article
The direct synthesis of C(CF3)Me2-substituted heteroarenes by decarboxylative 1,1-dimethyltrifluoroethylation of heteroarenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid is reported. This method does not need the transition-metal catalyst, and the base is crucial for this reaction. A series of previously unknown C(CF3)Me2-containing heteroarenes were obtained in high yields and have potential applications in the drug discovery process.
