E-viri
Recenzirano
Odprti dostop
-
Loveridge, Carolyn J; Mui, Ernest J; Patel, Rachana; Tan, Ee Hong; Ahmad, Imran; Welsh, Michelle; Galbraith, Julie; Hedley, Ann; Nixon, Colin; Blyth, Karen; Sansom, Owen; Leung, Hing Y
Cancer research, 06/2017, Letnik: 77, Številka: 12Journal Article
Prostate cancer does not appear to respond to immune checkpoint therapies where T-cell infiltration may be a key limiting factor. Here, we report evidence that ablating the growth regulatory kinase can increase T-cell infiltration in an established -deficient mouse model of human prostate cancer. Mice that were doubly mutant in prostate tissue for and (prostate DKO) exhibited a markedly increased median survival with reduced tumor size and proliferation compared with control -mutant mice, the latter of which exhibited increased mRNA expression. A comparative transcriptomic analysis revealed upregulation in prostate DKO mice of the chemokines and , two potent chemoattractants for T lymphocytes. Consistent with this effect, we observed a relative increase in a predominantly CD4 T-cell infiltrate in the prostate epithelial and stroma of tumors from DKO mice. Collectively, our results offer a preclinical proof of concept for ERK5 as a target to enhance T-cell infiltrates in prostate cancer, with possible implications for leveraging immune therapy in this disease. .
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.