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Shen, X L; Nielsen, M; Witt, M R; Sterner, O; Bergendorff, O; Khayyal, M
Zhōngguó yàolĭ xuébào, 09/1994, Letnik: 15, Številka: 5Journal Article
Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of methyl-3Hdiazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in 35S TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.
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