Two new species, Aegiphila aracaensis from Brazil and A. hystricina from Venezuela, are described and illustrated, and their relationships with allied species are discussed. Aegiphila aracaensis shares morphological similarities with A. venezuelensis Moldenke, although it differs in leaf shape, length, and width, and in the corolla tube externally covered by a denser canescent indument. Aegiphila hystricina is a shrub to small tree distinguished by its congested elongate inflorescences, and the flowers subtended by three bracteoles covered by glandular trichomes, 8- to 10-septate. The species is related to Aegiphila arcta Moldenke, but differs from it in leaf shape, length, and width, petiolate leaves, and larger glandular trichomes.