Practical guidance for navigating issues associated with combining mixed methods and case study research approaches is in short supply, particularly for novice researchers who may grapple with numerous decision points in planning and conducting such studies. This methodological discussion examines the decision-making process used in a qualitatively driven mixed methods dissertation study with a focus on how mixed methods and case study research approaches can be applied together to enhance case descriptions and interpretations. This discussion contributes to the field of mixed methods research methodology by expanding conversations about the inherent messiness of mixed methods research and by providing practical guidance to researchers interested in applying a mixed methods case study approach.