The concept of eco-industrial parks (EIPs) for integrating resources and infrastructure among several adjacent plants offers synergistic opportunities that can lead to enhanced profit, reduced pollution, and increased conservation of natural resources. A special class of EIPs, carbon-hydrogen-oxygen symbiosis networks (CHOSYNs), has been recently introduced for integrating hydrocarbon processing plants. The synthesis of CHOSYNs establishes multiscale benchmarks for the design by tracking the atomic fluxes of carbon, hydrogen, and oxygen atoms to develop rigorous performance benchmarks. Multiscale process synthesis techniques are then used to generate system configurations that achieve the benchmarks and to establish tradeoffs among various objectives. To date, all published research contributions for optimizing the design of CHOSYNs have focused on integrating mass among the participating plants. Opportunities exist to further increase resource efficiency by also incorporating energy integration into the design of CHOSYNs. This work addresses the design of CHOSYN through the inclusion of mass and energy integration in the benchmarking and synthesis of the network configurations. In addition to the benefits from mass and heat integration, further reduction of resource usage is explored through the incorporation of an integrated trigeneration facility. The design of CHOSYNs is evaluated by assessing economic and environmental objectives. A case study is established and solved demonstrating the mass and energy targeting techniques of this approach. Significant economic savings and sustainability enhancements of each participating plant in the CHOSYN are obtained. The outcome of the case study displays the synergistic relationship between each participating plant.