This study examines the agenda-setting power of fake news and fact-checkers who fight them through a computational look at the online mediascape from 2014 to 2016. Although our study confirms that content from fake news websites is increasing, these sites do not exert excessive power. Instead, fake news has an intricately entwined relationship with online partisan media, both responding and setting its issue agenda. In 2016, partisan media appeared to be especially susceptible to the agendas of fake news, perhaps due to the election. Emerging news media are also responsive to the agendas of fake news, but to a lesser degree. Fake news coverage itself is diverging and becoming more autonomous topically. While fact-checkers are autonomous in their selection of issues to cover, they were not influential in determining the agenda of news media overall, and their influence appears to be declining, illustrating the difficulties fact-checkers face in disseminating their corrections.