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Wang, Feng; He, Ming-Ming; Xiao, Jian; Zhang, Yan-Qiao; Yuan, Xiang-Lin; Fang, Wei-Jia; Zhang, Yan; Wang, Wei; Hu, Xiao-Hua; Ma, Zhi-Gang; Yao, Yi-Chen; Zhuang, Zhi-Xiang; Zhou, Fu-Xiang; Ying, Jie-Er; Yuan, Ying; Zou, Qing-Feng; Guo, Zeng-Qing; Wu, Xiang-Yuan; Jin, Ying; Mai, Zong-Jiong; Wang, Zhi-Qiang; Qiu, Hong; Guo, Ying; Shi, Si-Mei; Chen, Shuang-Zhen; Luo, Hui-Yan; Zhang, Dong-Sheng; Wang, Feng-Hua; Li, Yu-Hong; Xu, Rui-Hua
Clinical cancer research, 10/2022, Letnik: 28, Številka: 19Journal Article
To compare the efficacy and safety of high-dose vitamin C plus FOLFOX ± bevacizumab versus FOLFOX ± bevacizumab as first-line treatment in patients with metastatic colorectal cancer (mCRC). Between 2017 and 2019, histologically confirmed patients with mCRC (n = 442) with normal glucose-6-phosphate dehydrogenase status and no prior treatment for metastatic disease were randomized (1:1) into a control (FOLFOX ± bevacizumab) and an experimental high-dose vitamin C (1.5 g/kg/d, intravenously for 3 hours from D1 to D3) plus FOLFOX ± bevacizumab group. Randomization was based on the primary tumor location and bevacizumab prescription. The progression-free survival (PFS) of the experimental group was not superior to the control group median PFS, 8.6 vs. 8.3 months; HR, 0.86; 95% confidence interval (CI), 0.70-1.05; P = 0.1. The objective response rate (ORR) and overall survival (OS) of the experimental and control groups were similar (ORR, 44.3% vs. 42.1%; P = 0.9; median OS, 20.7 vs. 19.7 months; P = 0.7). Grade 3 or higher treatment-related adverse events occurred in 33.5% and 30.3% of patients in the experimental and control groups, respectively. In prespecified subgroup analyses, patients with RAS mutation had significantly longer PFS (median PFS, 9.2 vs. 7.8 months; HR, 0.67; 95% CI, 0.50-0.91; P = 0.01) with vitamin C added to chemotherapy than with chemotherapy only. High-dose vitamin C plus chemotherapy failed to show superior PFS compared with chemotherapy in patients with mCRC as first-line treatment but may be beneficial in patients with mCRC harboring RAS mutation.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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