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Spontaneous Regression of Primary Abdominal Wall Desmoid Tumors: More Common than Previously ThoughtBonvalot, Sylvie; Ternès, Nils; Fiore, Marco; Bitsakou, Georgina; Colombo, Chiara; Honoré, Charles; Marrari, Andrea; Le Cesne, Axel; Perrone, Federica; Dunant, Ariane; Gronchi, Alessandro
Annals of surgical oncology, 12/2013, Letnik: 20, Številka: 13Journal Article
Purpose The relevance of the initial observational approach for desmoid tumors (DTs) remains unclear. We investigated a new conservative management treatment for primary abdominal wall DTs. Methods Data were collected from 147 patients between 1993 and 2012. The initial therapeutic approaches were categorized as front-line surgery surgery group (SG), n = 41, 28 % and initial observation or medical treatment nonsurgery group (NSG), n = 106, 72 %. The cumulative incidence of the last strategy modification was estimated using competing risk methods with variable censoring times. Results Of the 147 patients, 143 were female (97 %). In the SG, 27 patients (66 %) required full-thickness abdominal wall mesh repair. In the NSG, 102 patients (96 %) underwent initial observation and four received medical treatment. In the NSG, the 1- and 3-year incidences of changing to medical treatment (no further changes during the follow-up) were 19 % 95 % confidence interval (CI) 11–28 and 25 % (95 % CI 17–35), respectively, and the 1- and 3-year incidences of a final switch to surgery were 14 % (95 % CI 8–22) and 16 % (95 % CI 9–24), respectively. An initial tumor size of >7 cm was associated with a higher strategy modification risk ( p = 0.004). Of the 102 patients initially observed, 29 experienced spontaneous regression over a median follow-up period of 32 months. All second-intent resections were macroscopically completed, with R0 resections achieved in 82 % of patients. Conclusions This study supports an initial nonsurgical approach to abdominal wall DTs ≤7 cm, followed by surgery based on tumor growth in select cases.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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