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Inoue, Yu; Hasebe, Yuichi; Igarashi, Toshio; Kawagishi‐Hotta, Mika; Okuno, Ryosuke; Yamada, Takaaki; Hasegawa, Seiji
Experimental dermatology, December 2021, 2021-12-00, 20211201, Letnik: 30, Številka: 12Journal Article
The constitution and skin type of individuals are influenced by various factors. Recently, the influence of genetic predispositions on these has been emphasized. To date, genome‐wide association studies (GWAS) have shown several single nucleotide polymorphisms (SNPs) that affect individual's constitution and skin type. However, these studies have mainly focused on the Caucasian population, and only a few association analyses with the constitution and skin type of individuals involving a Japanese population have been conducted. In this study, we conducted a GWAS analysis of 9 phenotypes regarding the constitution or skin type of 1108 Japanese women based on a questionnaire. As a result, in addition to SNPs known to be involved in phenotypes in the past, we discovered new SNPs and genetic regions related to darkness of pigmented spots, skin flushing, frequency of rough skin and responsiveness to cosmetics. In this study, we conducted a GWAS analysis of 9 phenotypes for the constitution or skin type of Japanese women, and found new SNPs and gene regions associated with the darkness of pigment spots, skin flushing, frequency of rough skin and responsiveness to cosmetics.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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