Seizures were induced in rats using repetitive injections of picrotoxin, PTX (i.p., every 30 min in a dose of 0.9 mg/kg in the first injection and 0.7 mg/kg in subsequent injections). Picamilon (PM) and isopicamilon (IPM) in doses of 20 or 50 mg/kg were i.p. injected into animals 30 min prior to injection of PTX. Epileptiform activity (EFA), recorded from the cerebral structures under conditions of preliminary systemic injections of PM and IPM, could be divided into two types characterized by exclusive development of only spike-wave discharges, SWDs (61.3 %) and regular cortical spike activity with generation of separate short-lasting SWDs (38.7%). In rats with EFA of the first type, the frequency and duration of seizure SWDs decreased significantly after injections of PM and IPM in doses of 50 mg/kg. In rats with EFA of the second type, the intensity of SWDs decreased even after injections of these agents in smaller doses (20 mg/kg). The use of IPM as an agent with a protective anticonvulsive action was more effective.