The politicization of climate change and the difficulty of achieving multi-level or sectoral stakeholder coordination are common institutional barriers to effective climate change adaptation governance outcomes. In the U.S., quasi-government organizations (QGOs) were designed to overcome such barriers, albeit traditionally for non-climatic purposes. This study’s objective is to illustrate how the design characteristics of QGOs may be useful for overcoming the above climate adaptation barriers. Methodologically, this paper analyzes six case studies, selected to illustrate the major characteristics of QGOs, of climate-focused and non climate-focused QGOs at the sub-national level in the U.S. Non climate-focused examples are included for comparison with, and to supplement, the limited number of QGOs currently working on climate efforts. For each case, this study focuses on eight design characteristics: seven that represent measures of political and financial independence, and one focused on board composition, to illustrate the extent to which QGOs enable multi-level and multi-sectoral stakeholder coordination. This study finds that among the assortment of existing QGO designs some are particularly well suited to overcoming either the politicization of climate adaptation policy or obstacles to enhancing policy coordination, while some reduce both, albeit to a lesser extent. Broadly, this paper concludes that QGOs can strengthen effective action by depoliticizing informational sources and fostering cross scale coordination of planning and implementation.