Abstract Objectives To evaluate the impact of oral health status on bacteremia risk in a cohort of acute myeloid leukemia (AML) patients who underwent chemotherapy followed by myeloablative allogeneic hematopoietic cell transplantation (alloHCT). Materials and Methods A retrospective study was conducted in patients with AML from 2007 to 2011. Oral health status was determined from a pre-alloHCT dental evaluation. Positive blood cultures were recorded from AML induction to day +60 post alloHCT. Organisms that caused bacteremia were classified as “of possible oral source” by a blinded microbiologist. Two-sided Fisher’s exact test was used to compare the oral health status of the entire cohort to patients with blood cultures of potential oral source. Results Pre-alloHCT dental evaluations were completed in 91/92 (99%) of patients. Of the 13/91 (14%) patients with dental pathology, 13/13 (100%) completed all required dental treatment prior to alloHCT. Bacteremias occurred in 63/92 (68%) patients, and 12/63 (19%) had positive blood cultures of potential oral source. Of these, 1/12 patient developed bacteremia during AML induction and 11/12 patients developed bacteremia during alloHCT. Conclusion Oral health status was not associated with risk of bacteremia of potential oral source at either AML induction/consolidation or alloHCT.